Springer Theses

Fluorescent Tools for Imaging Oxidative Stress in Biology

Authors: Kaur, Amandeep

  • Nominated as an outstanding Ph.D. thesis by the University of Sydney, Australia
  • Outlines new reversible fluorescent redox sensors to visualise subcellular oxidative stress
  • Demonstrates successful applications of redox sensors in a variety of biological systems
  • Provides clear explanations for chemists and biologists alike
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書籍の購入

イーブック 118,99 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-73405-7
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー 139,99 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-73404-0
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
この書籍について

This thesis advances the long-standing challenge of measuring oxidative stress and deciphering its underlying mechanisms, and also outlines the advantages and limitations of existing design strategies. It presents a range of approaches for the chemical synthesis of fluorescent probes that detect reversible changes in cellular oxidative stress. The ability to visualise cellular processes in real-time is crucial to understanding disease development and streamline treatment, and this can be achieved using fluorescent tools that can sense reversible disturbances in cellular environments during pathogenesis. The perturbations in cellular redox state are of particular current interest in medical research, since oxidative stress is implicated in the pathogenesis of a number of diseases.

The book investigates different strategies used to achieve ratiometric fluorescence output of the reversible redox probes, which nullify concentration effects associated with intensity-based probes. It also describes suitable approaches to target these probes to specific cellular organelles, thereby enabling medical researchers to visualise sub-cellular oxidative stress levels, and addressing the typically poor uptake of chemical tools into biological studies.

In total it reports on four new probes that are now being used by over twenty research groups around the globe, and two of which have been commercialised. The final chapters of this thesis demonstrate successful applications of the sensors in a variety of biological systems ranging from prokaryotes to mammalian cells and whole organisms. The results described clearly indicate the immense value of collaborative, cross-disciplinary research.

著者について

Amandeep Kaur completed her master’s studies in chemistry, with a University medal from VIT University, India in 2012. She then took up a research internship at ENSCCF, France, where she worked on the development of transition metal-doped calcium phosphate ceramics. Amandeep completed her Ph.D. in 2016 at the University of Sydney with Dr Elizabeth New, during which she was awarded a World Scholars Scholarship. Her Ph.D. research involved the development of reversible fluorescent redox sensors for understanding the role of oxidative stress in biological systems. She is currently working as a postdoctoral research fellow at the EMBL Australia Node in Single Molecule Science, University of New South Wales, Australia.

Table of contents (10 chapters)

  • Introduction

    Kaur, Amandeep

    Pages 1-36

    Preview Buy Chapter 26,95 €
  • Flavin Based Redox Probes

    Kaur, Amandeep

    Pages 37-57

    Preview Buy Chapter 26,95 €
  • FRET Based Ratiometric Redox Probes

    Kaur, Amandeep

    Pages 59-91

    Preview Buy Chapter 26,95 €
  • Mitochondrially-Targeted Ratiometric Redox Probes

    Kaur, Amandeep

    Pages 93-111

    Preview Buy Chapter 26,95 €
  • Nicotinamide Based Ratiometric Redox Probes

    Kaur, Amandeep

    Pages 113-128

    Preview Buy Chapter 26,95 €

書籍の購入

イーブック 118,99 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-73405-7
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー 139,99 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-73404-0
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
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書誌情報

Bibliographic Information
Book Title
Fluorescent Tools for Imaging Oxidative Stress in Biology
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
イーブック ISBN
978-3-319-73405-7
DOI
10.1007/978-3-319-73405-7
ハードカバー ISBN
978-3-319-73404-0
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XLV, 230
Topics