Protein Deimination in Human Health and Disease

Editors: Nicholas, Anthony, Bhattacharya, Sanjoy, Thompson, Paul (Eds.)

  • Updates the latest developments in deimination research
  • Includes contributions from key authors world-wide
  • Provides a detailed history of the first experiments that set the foundation for this field of research
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eBook 166,59 €
price for Spain (gross)
  • ISBN 978-3-319-58244-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 207,99 €
price for Spain (gross)
  • ISBN 978-3-319-58243-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

Published in 2014, Protein Deimination in Human Health and Disease was the first book on this novel post-translational modification, in which selected positively-charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl-arginine deiminase (PAD) family of enzymes. This area of research continues to expand rapidly, necessitating the need for this second edition. Chronicling the latest inflammatory, epigenetic, neurodegenerative, and carcinogenic processes, Protein Deimination in Human Health and Disease, Second Edition, updates the latest advances in deimination research, including new information on PAD enzyme structure and activity, and how PAD knock-out animals are being used to study known and newly-discovered links to various human diseases.

The first edition outlined what was known about citrullinated proteins in normal tissues such as skin and hair, as well as in maladies such as rheumatoid arthritis (RA), multiple sclerosis (MS), Alzheimer’s disease (AD), glaucoma, peripheral nerve injury, neonatal hypoxic brain damage, and breast cancer. This second edition addresses numerous additional disorders such as diabetes, asthma, traumatic brain injury, inflammatory bowel disease, lupus, bone disease, heart failure, fronto-temporal dementia, and prostate and colon cancer. It also provides updates on the deimination research covering the three seminal diseases first linked to this process (RA, MS and AD), and details how auto-antibodies against citrullinated proteins contribute to disease. In addition, new hypotheses on the possible pathologic mechanisms of citrullinated myelin basic protein and glial fibrillary acidic protein are also proposed. This second edition also outlines the latest developments in therapeutic strategies, including the use of new PAD antagonists and innovative techniques such as micro-vescicles and stem cells as possible mechanisms to treat these conditions.

About the authors

Anthony Nicholas, University of Alabama - BirminghamSanjoy Bhattacharya, University of MiamiPaul R. Thompson, University of Massachusetts Medical School 

Table of contents (23 chapters)

  • A History of Deimination Research in Japan: The Founding Fathers

    Takahara, Hidenari

    Pages 1-10

    Preview Buy Chapter 30,19 €
  • Aspects of Peptidylarginine Deiminase Regulation that May Predispose to Autoreactivity Against Citrullinated Proteins

    Neeli, Indira, Ph.D. (et al.)

    Pages 11-32

    Preview Buy Chapter 30,19 €
  • Structures and Functions of Peptidylarginine Deiminases

    Unno, Masaki (et al.)

    Pages 33-46

    Preview Buy Chapter 30,19 €
  • The Use of Genetically Engineered Mice to Study PAD Biology and Pathology

    Mukai, Chinatsu (et al.)

    Pages 47-61

    Preview Buy Chapter 30,19 €
  • PAD Activation in Arthritis

    Damgaard, Dres (et al.)

    Pages 63-83

    Preview Buy Chapter 30,19 €

Buy this book

eBook 166,59 €
price for Spain (gross)
  • ISBN 978-3-319-58244-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 207,99 €
price for Spain (gross)
  • ISBN 978-3-319-58243-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Protein Deimination in Human Health and Disease
Editors
  • Anthony Nicholas
  • Sanjoy Bhattacharya
  • Paul Thompson
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-58244-3
DOI
10.1007/978-3-319-58244-3
Hardcover ISBN
978-3-319-58243-6
Edition Number
2
Number of Pages
IX, 474
Number of Illustrations and Tables
35 b/w illustrations, 81 illustrations in colour
Topics