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Protein Deimination in Human Health and Disease

Editors: Nicholas, Anthony, Bhattacharya, Sanjoy, Thompson, Paul (Eds.)

  • Updates the latest developments in deimination research
  • Includes contributions from key authors world-wide
  • Provides a detailed history of the first experiments that set the foundation for this field of research
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書籍の購入

イーブック 166,59 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-58244-3
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー 199,99 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-58243-6
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
この書籍について

Published in 2014, Protein Deimination in Human Health and Disease was the first book on this novel post-translational modification, in which selected positively-charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl-arginine deiminase (PAD) family of enzymes. This area of research continues to expand rapidly, necessitating the need for this second edition. Chronicling the latest inflammatory, epigenetic, neurodegenerative, and carcinogenic processes, Protein Deimination in Human Health and Disease, Second Edition, updates the latest advances in deimination research, including new information on PAD enzyme structure and activity, and how PAD knock-out animals are being used to study known and newly-discovered links to various human diseases.

The first edition outlined what was known about citrullinated proteins in normal tissues such as skin and hair, as well as in maladies such as rheumatoid arthritis (RA), multiple sclerosis (MS), Alzheimer’s disease (AD), glaucoma, peripheral nerve injury, neonatal hypoxic brain damage, and breast cancer. This second edition addresses numerous additional disorders such as diabetes, asthma, traumatic brain injury, inflammatory bowel disease, lupus, bone disease, heart failure, fronto-temporal dementia, and prostate and colon cancer. It also provides updates on the deimination research covering the three seminal diseases first linked to this process (RA, MS and AD), and details how auto-antibodies against citrullinated proteins contribute to disease. In addition, new hypotheses on the possible pathologic mechanisms of citrullinated myelin basic protein and glial fibrillary acidic protein are also proposed. This second edition also outlines the latest developments in therapeutic strategies, including the use of new PAD antagonists and innovative techniques such as micro-vescicles and stem cells as possible mechanisms to treat these conditions.

著者について

Anthony Nicholas, University of Alabama - BirminghamSanjoy Bhattacharya, University of MiamiPaul R. Thompson, University of Massachusetts Medical School 

Table of contents (23 chapters)

  • A History of Deimination Research in Japan: The Founding Fathers

    Takahara, Hidenari

    Pages 1-10

    Preview Buy Chapter 26,95 €
  • Aspects of Peptidylarginine Deiminase Regulation that May Predispose to Autoreactivity Against Citrullinated Proteins

    Neeli, Indira, Ph.D. (et al.)

    Pages 11-32

    Preview Buy Chapter 26,95 €
  • Structures and Functions of Peptidylarginine Deiminases

    Unno, Masaki (et al.)

    Pages 33-46

    Preview Buy Chapter 26,95 €
  • The Use of Genetically Engineered Mice to Study PAD Biology and Pathology

    Mukai, Chinatsu (et al.)

    Pages 47-61

    Preview Buy Chapter 26,95 €
  • PAD Activation in Arthritis

    Damgaard, Dres (et al.)

    Pages 63-83

    Preview Buy Chapter 26,95 €

書籍の購入

イーブック 166,59 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-58244-3
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー 199,99 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-58243-6
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
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書誌情報

Bibliographic Information
Book Title
Protein Deimination in Human Health and Disease
Editors
  • Anthony Nicholas
  • Sanjoy Bhattacharya
  • Paul Thompson
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
イーブック ISBN
978-3-319-58244-3
DOI
10.1007/978-3-319-58244-3
ハードカバー ISBN
978-3-319-58243-6
Edition Number
2
Number of Pages
IX, 474
Number of Illustrations and Tables
35 b/w illustrations, 81 illustrations in colour
Topics