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Biomolecular Interfaces

Interactions, Functions and Drug Design

Authors: Fernandez Stigliano, Ariel

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  • Casts new light on bio molecular interactions
  • Will be of interest to researchers and graduate students in chemistry, biophysics and biomedical engineering
  • Problems and solutions in each frontier topic allow readers to broaden their understanding
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書籍の購入

イーブック ¥8,396
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-319-16850-0
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: PDF, EPUB
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー ¥10,529
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-319-16849-4
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
ソフトカバー ¥10,495
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-319-36814-6
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
この教本について

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior.

The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

著者について

The author is Ariel Fernandez Stigliano, who is an Argentinian–American theoretical chemist and mathematician, and heads his own pharmaceutical consultancy, Ariel Fernandez Innovation, at the Argentine National Scientific and Technical Research Council (CONICET) and at Collegium Basilea, the Institute of Advanced Study in Basel, Switzerland. Addresses: Avenida del Libertador 1092 – Piso 1 Buenos Aires 1112, Argentina 1419 Montrose Blvd. #305 Houston, TX 77019, USA Current Positions: * Senior Investigator, Argentine National Research Council (CONICET) (2011-). Instituto Argentino de Matemática, “Alberto P. Calderón", 1083 Buenos Aires, Argentina * Honorary Investigator, Collegium Basilea, Institute of Advanced Study, CH 4053 Basel, Switzerland (2006-) * Visiting Professor, National Tsing-Hua University, Hsinchu, Republic of China (2010-) · President, AF Innovation, SRL, a Pharmaceutical Consultancy (2010-). * Vice president and Chief Scientific Officer at Ariel Fernandez Consultancy, GmbH, a Biotechnology firm specialized in dynamic molecular design (2013-)

Table of contents (15 chapters)

Table of contents (15 chapters)
  • The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology

    Pages 1-33

    Fernández Stigliano, Ariel

  • Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water

    Pages 35-51

    Fernández Stigliano, Ariel

  • Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches

    Pages 53-82

    Fernández Stigliano, Ariel

  • Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface

    Pages 83-96

    Fernández Stigliano, Ariel

  • Proteins in the Order–Disorder Twilight: Unstable Interfaces Promote Protein Aggregation

    Pages 97-126

    Fernández Stigliano, Ariel

書籍の購入

イーブック ¥8,396
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-319-16850-0
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: PDF, EPUB
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー ¥10,529
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-319-16849-4
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
ソフトカバー ¥10,495
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-319-36814-6
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
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書誌情報

Bibliographic Information
Book Title
Biomolecular Interfaces
Book Subtitle
Interactions, Functions and Drug Design
Authors
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
イーブック ISBN
978-3-319-16850-0
DOI
10.1007/978-3-319-16850-0
ハードカバー ISBN
978-3-319-16849-4
ソフトカバー ISBN
978-3-319-36814-6
Edition Number
1
Number of Pages
XIX, 372
Number of Illustrations
86 b/w illustrations, 59 illustrations in colour
Topics