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  • © 2021

Uveal Melanoma

Biology and Management

  • Exclusively reviews the history and management of uveal melanoma
  • Describes both surgical management and systemic therapies
  • Reviews predisposed genetic syndromes and gene expression profiling
  • Written and edited by experts in the field of oncology, ophthalmology, radiology, and pathology

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
  2. Basic Science

    1. Front Matter

      Pages 1-1
    2. Molecular Basis of Uveal Melanoma and Emerging Therapeutic Targets

      • J. William Harbour, Zelia M. Correa
      Pages 3-12
    3. Clinical/Commercial Genetic Testing in UM

      • Thomas M. Aaberg Jr, Aditya Shah
      Pages 13-22
    4. BAP1 Tumor Predisposition Syndrome

      • Sarah Smith, Mohamed H. Abdel-Rahman, Robert Pilarski, Frederick H. Davidorf, Colleen M. Cebulla
      Pages 23-36
    5. Pathology of Uveal Melanoma

      • Patricia Chévez-Barrios
      Pages 37-51
    6. Uveal Melanoma: Epidemiology of Uveal Melanoma and Potential Clusters

      • Asghar A. Haider, John O. Mason III
      Pages 53-58
  3. Management of the Eye

    1. Front Matter

      Pages 67-67
    2. Surgical Considerations of Radiation Plaques and Enucleation

      • Amy C. Schefler, Hannah J. Yu
      Pages 69-88
    3. Uveal Melanoma: Imaging

      • Jose R. Davila, Prithvi Mruthyunjaya
      Pages 89-101
    4. Radiation Therapy in Ocular Melanoma

      • Andrew J. Wong, Bin S. Teh
      Pages 103-114
    5. Late Complications of Radiation Therapy in Uveal Melanoma

      • Hannah J. Yu, Andrew J. Wong, Bin S. Teh, Amy C. Schefler
      Pages 115-133
    6. Nanoparticles for the Treatment of Uveal Melanoma

      • Abhijit Narvekar, Cadmus Rich, Anneli Savinainen, Ivana K. Kim
      Pages 135-149
  4. Systemic Therapies

    1. Front Matter

      Pages 151-151
    2. Surveillance for Metastatic Disease

      • Caroline A. Nebhan, Douglas B. Johnson, Steven A. Deppen, Anthony B. Daniels
      Pages 153-171
    3. Adjuvant Therapy of Uveal Melanoma

      • Leonel Hernandez-Aya, Jose Lutzky
      Pages 173-192
    4. Liver-Directed Therapies for Hepatic Metastases

      • Flavio E. Baio, Barrett C. Riddle, Mark A. Sultenfuss, Nestor F. Esnaola
      Pages 193-202
    5. Systemic Therapy for Metastatic Uveal Melanoma

      • Eric H. Bernicker
      Pages 203-212
    6. Cell Therapy for Uveal Melanoma

      • Cesar Gentille Sanchez, Thomas Pfeiffer, Bilal A. Omer
      Pages 213-225

About this book

This book provides a comprehensive examination of uveal melanoma, a rare neoplasm that carries a very high mortality and whose natural history makes it fairly unique among adult tumors. Split into three sections, this book explores the basic science behind the disease and inherited genetic syndromes that predispose some patients, as well as the pathology and use of gene expression profiling to determine risk of recurrence. It also focuses on the management of the primary tumor in the eye, including surgical intervention and lesion imaging. Elucidating treatment options for metastatic disease, the book reviews chemotherapy agents and immunotherapy approaches, as well as liver-directed therapies, cellular therapies, and various treatments after primary treatment but before the development of metastases.

Uveal Melanoma: Biology and Management is the most up-to-date and comprehensive text devoted solely to this disease and will be useful to medical oncologists, ophthalmologists, radiation therapists, interventional radiologists, pathologists, molecular biologists and immunology researchers, as well as trainees in those fields.



Editors and Affiliations

  • Cancer Center, Houston Methodist Hospital, Houston, USA

    Eric H. Bernicker

About the editor

Eric H. BernickerCancer Center, Houston Methodist Hospital
6445 Main Street, OPC 24
Houston, Texas 77030
USA




Bibliographic Information

  • Book Title: Uveal Melanoma

  • Book Subtitle: Biology and Management

  • Editors: Eric H. Bernicker

  • DOI: https://doi.org/10.1007/978-3-030-78117-0

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Softcover ISBN: 978-3-030-78116-3Published: 05 August 2021

  • eBook ISBN: 978-3-030-78117-0Published: 03 August 2021

  • Edition Number: 1

  • Number of Pages: XI, 229

  • Number of Illustrations: 5 b/w illustrations, 36 illustrations in colour

  • Topics: Oncology, Ophthalmology, Imaging / Radiology

Buy it now

Buying options

eBook USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access