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  • © 2021

Sex-Based Differences in Lung Physiology

  • Highlights known factors relating to sex disparities appearing in lung disease
  • Offers insights on sex-specific mechanisms of lung inflammation and immunity
  • Sheds a light on crosstalks between respiratory and reproductive systems in lung disease

Part of the book series: Physiology in Health and Disease (PIHD)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xx
  2. Sex Differences in Respiratory Physiology

    • Y. S. Prakash, Christina M. Pabelick, Sergio E. Chiarella
    Pages 1-11
  3. Sex Steroids and Their Influence in Lung Diseases Across the Lifespan

    • Niyati A. Borkar, Venkatachalem Sathish
    Pages 39-72
  4. Sex Differences in the Developing Lung: Implications for Disease

    • Joe G. Zein, Benjamin Gaston
    Pages 73-113
  5. Neonatal Lung Disease: Mechanisms Driving Sex Differences

    • Krithika Lingappan, Brielle Hayward-Piatkovskyi, Jason P. Gleghorn
    Pages 115-144
  6. Sex Differences in Cystic Fibrosis Across the Lifespan

    • Kubra Melike Bozkanat, Raksha Jain
    Pages 145-168
  7. Sex Differences in Chronic Obstructive Pulmonary Disease

    • Michael Ferrera, Mei Lan K. Han
    Pages 169-195
  8. Sex Differences in Pulmonary Arterial Hypertension

    • Andrea L. Frump, Larissa A. Shimoda
    Pages 197-249
  9. Sex and Gender Differences in the Susceptibility to Environmental Exposures

    • Patricia Silveyra, Heba Al Housseiny, Meghan E. Rebuli
    Pages 251-290
  10. Sex Differences in Adaptive Immunity in Chronic Lung Disease

    • Nowrin U. Chowdhury, Vivek D. Gandhi, Dawn C. Newcomb
    Pages 323-343
  11. Sex Differences in Respiratory Infection

    • Valerie F. L. Yong, Tavleen K. Jaggi, Louisa L. Y. Chan, Sanjay H. Chotirmall
    Pages 365-404
  12. Androgen Excess in Women and the Respiratory System

    • Licy L. Yanes Cardozo, Samar Rezq, Jacob E. Pruett, Vishnu V. Garla, Damian G. Romero
    Pages 405-428
  13. Sex Differences in Circadian Biology: Influences on Lung Health and Disease

    • Ashokkumar Srinivasan, Isaac Kirubakaran Sundar
    Pages 429-469
  14. Sex Differences in the Coronavirus Disease 2019

    • Sergio E. Chiarella, Christina Pabelick, Y. S. Prakash
    Pages 471-490

About this book

This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology.

In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung’s innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease.

To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.

Editors and Affiliations

  • Department of Environmental and Occupational Health, Indiana University Bloomington, School of Public Health, Bloomington, USA

    Patricia Silveyra

  • Office of Research on Women’s Health, Office of the Director, National Institutes of Health Bethesda, Bethesda, USA

    Xenia T. Tigno

About the editors

Dr. Patricia Silveyra is a Distinguished Associate Professor, Director of the Biobehavioral Laboratory, and member of the Center for Environmental Medicine, Asthma, and Lung Biology (CEMALB) at the University of North Carolina at Chapel Hill. Her research interests are on sex and gender differences in inflammatory lung disease. She specifically studies mechanisms by which sex hormones control inflammatory responses in the lung using mouse and cell models. Dr. Silveyra has published over 50 scientific articles in peer-reviewed journals. She has served as principal investigator, co-principal investigator, and co-investigator on University-, foundation- and NIH-funded grants. She is a former scholar of the NICHD K12, Building Interdisciplinary Research Careers in Women’s Health (BIRCWH), and the NHLBI Programs to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE). Dr. Silveyra was born and raised in Argentina, where she earned her bachelor’s and master’s degrees in Molecular Biology and Biotechnology, and her PhD in Biochemistry, from the University of Buenos Aires. She moved to the United States as postdoctoral fellow and Rotary Ambassadorial Scholar. Dr. Silveyra is a member and co-chair of the National Academies of Sciences, Engineering and Medicine (NASEM) “New Voices” program, and a member of the NASEM Board on Higher Education and Workforce.

 

Dr. Xenia T. Tigno is the Associate Director for Careers at the Office of Research on Women’s Health, National Institutes of Health, Bethesda, MD. Prior to her current position, she was a Program Officer at the National Heart, Lung, and Blood Institute of the NIH and of the National Institute for Nursing Research. Dr. Tigno has published in the areas of the biophysics of the microcirculation, obesity, diabetes, aging, community-based epidemiology, chaos analysis, herbal medicine, and women’s health. She taught medical physiology for nearly 30 years, includingserving as Professor and Chair of the Department of Physiology, University of the Philippines College of Medicine, and coordinator of the Medical Physiology course at the University of South Florida. A native of Manila, Philippines, Dr. Tigno obtained her Bachelor’s degree in Physics, and Master’s degrees in both Physiology and Epidemiology from the University of the Philippines, and her Doctorate in Natural Science degree from the University of Wurzburg, Federal Republic of Germany. As a bench scientist, she has worked in various laboratories, including at the CERN (European Organization for Nuclear Research) in Geneva, at the Physiological Institutes in Wurzburg, Munich, and Berlin, and at the National Cardiovascular Institute in Osaka.  She has previously edited a textbook on Integrative Physiology. Dr. Tigno’s current efforts are directed towards supporting the advancement of women in biomedical careers, and promoting diversity and inclusion in academia.

Bibliographic Information

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access