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Cardiac Bioelectric Therapy

Mechanisms and Practical Implications

  • Reviews the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy

  • Discusses novel arrhythmia therapies such as leadless pacing, low energy defibrillation, machine learning, and high-resolution mapping

  • Highlights breakthrough technologies for scientific and clinical investigation of heart rhythm disorders

  • Provides an in-depth examination of implantable devices technology and security

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-xiii
  2. History of Electrotherapy

    1. Front Matter

      Pages 1-1
    2. History of Cardiac Pacing

      • Srijoy Mahapatra
      Pages 3-9
    3. History of Defibrillation

      • Hana Akselrod, Mark W. Kroll, Michael V. Orlov
      Pages 11-26
    4. The History of Mapping

      • Ivan Cakulev, Andrew L. Wit, Albert L. Waldo
      Pages 27-40
    5. History of Optical Mapping

      • Sharon A. George
      Pages 41-45
  3. Theory of Electric Stimulation and Defibrillation

    1. Front Matter

      Pages 47-47
    2. The Bidomain Theory of Stimulation

      • Deborah L. Janks, Bradley J. Roth
      Pages 49-59
    3. Bidomain Model of Defibrillation

      • Natalia Trayanova, Gernot Plank
      Pages 61-76
    4. The Generalized Activating Function

      • Leslie Tung
      Pages 77-89
  4. Electrode Mapping and Defibrillation

    1. Front Matter

      Pages 91-91
    2. Extracellular Mapping of Arrhythmias

      • Richard B. Schuessler
      Pages 93-106
    3. The Upper Limit of Vulnerability and Critical Points for Defibrillation

      • Derek J. Dosdall, Raymond E. Ideker
      Pages 107-119
    4. His-Purkinje Involvement in Arrhythmias and Defibrillation

      • Matthias Lange, Derek J. Dosdall
      Pages 121-132
  5. Optical Mapping of Stimulation and Defibrillation

    1. Front Matter

      Pages 133-133
    2. The Role of Microscopic Tissue Structure in Defibrillation

      • Andre G. Kleber, Anne M. Gillis
      Pages 135-145
    3. Virtual Electrode Theory of Pacing

      • Bradley J. Roth, Veniamin Y. Sidorov, John P. Wikswo
      Pages 147-179
    4. The Virtual Electrode Hypothesis of Defibrillation

      • Crystal M. Ripplinger, Igor R. Efimov
      Pages 181-197
    5. Advanced Three-Dimensional Optical Mapping

      • Olivier Bernus, Richard D. Walton
      Pages 199-208
  6. Methodology

    1. Front Matter

      Pages 209-209

About this book

The updated and expanded second edition of this book presents a contemporary review of the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy. It covers the rapidly expanding technological development of pacemakers and defibrillators as well as ablative therapy, electrophysiological mapping, and other clinical diagnostic and therapeutic breakthroughs. The book highlights many different aspects of bioelectric therapy, including history, biophysical and computational concepts, basic electrophysiology studies, engineering technology advances, and clinical perspectives.

In this revised edition, leading clinical and basic electrophysiologists share their perspectives on the science behind the mechanisms of cardiac arrhythmias; breakthrough technologies for scientific and clinical investigation of heart rhythm disorders; theoretical conceptualization of arrhythmias and treatment using state-of-the-art computational approaches; and novel approaches to treatment of cardiac arrhythmias using implantable devices, percutaneous ablation therapies, machine learning, and other approaches. 

The Second Edition of Cardiac Bioelectric Therapy is an essential resource for physicians, residents, fellows, and graduate students in clinical cardiac electrophysiology, cardiology, and cardiac surgery as well as researchers, professionals, and students in biomedical, mechanical, and electrical engineering. 





Editors and Affiliations

  • Department of Biomedical Engineering, The George Washington University, Washington, DC, USA

    Igor R. Efimov

  • National Heart & Lung Institute, Imperial College London, London, UK

    Fu Siong Ng

  • Philips EPD Solutions, Cambridge, USA

    Jacob I. Laughner

About the editors

Igor R. Efimov, Ph.D.
Alisann and Terry Collins Professor of Biomedical Engineering
Director, Cardiovascular Engineering Laboratory
The George Washington University
Washington, DC
USA



Fu Siong Ng, M.D., Ph.D.
Clinical Senior Lecturer in Cardiac Electrophysiology
Consultant Cardiologist & Cardiac Electrophysiologist 
National Heart & Lung Institute
Imperial College London
London
United Kingdom



Jacob Laughner, PhD
Research and Development
Philips Electrophysiology

Cambridge, MA 
USA

Bibliographic Information

  • Book Title: Cardiac Bioelectric Therapy

  • Book Subtitle: Mechanisms and Practical Implications

  • Editors: Igor R. Efimov, Fu Siong Ng, Jacob I. Laughner

  • DOI: https://doi.org/10.1007/978-3-030-63355-4

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-63354-7Published: 29 January 2021

  • Softcover ISBN: 978-3-030-63357-8Published: 29 January 2022

  • eBook ISBN: 978-3-030-63355-4Published: 28 January 2021

  • Edition Number: 2

  • Number of Pages: XIII, 432

  • Number of Illustrations: 91 b/w illustrations, 148 illustrations in colour

  • Topics: Cardiology, Cardiac Surgery, Biomedical Engineering/Biotechnology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access