Overview
- Nominated as an outstanding PhD thesis by the University of Toronto, Ontario, Canada
- Describes Pd-catalyzed domino reactions in a concise manner
- Provides a general overview of C-H activation
- Presents a novel Ni-catalyzed carbohalogenation reaction
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (3 chapters)
Keywords
About this book
This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon–carbon bonds in high atom- and step-economy.
In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, andhighlights its synthetic utility.
Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C–H activation and π-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.
Authors and Affiliations
About the author
Bibliographic Information
Book Title: Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles
Authors: Hyung Yoon
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-030-54077-7
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-54076-0Published: 03 September 2020
Softcover ISBN: 978-3-030-54079-1Published: 03 September 2021
eBook ISBN: 978-3-030-54077-7Published: 02 September 2020
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XXIX, 212
Number of Illustrations: 517 b/w illustrations, 35 illustrations in colour
Topics: Catalysis, Inorganic Chemistry, Organic Chemistry, Organometallic Chemistry, Physical Chemistry