Textbook of Oral Cancer

1. Front Matter

   Pages I-XIII

   PDF

2. Introduction – Cancers of the Mouth and Oropharynx

   • Saman Warnakulasuriya, John S. Greenspan

   Pages 1-4

3. Epidemiology of Oral and Oropharyngeal Cancers

   • Saman Warnakulasuriya, John S. Greenspan

   Pages 5-21

4. Risk Factors for Cancer of the Mouth: Tobacco, Betel Quid, and Alcohol

   • Mia Hashibe

   Pages 23-30

5. Human Papillomavirus Infection: A Risk Factor for Oral and Oropharyngeal Cancers

   • Giuseppina Campisi, Vera Panzarella

   Pages 31-45

6. Clinical Presentation and Differential Diagnosis of Oral Cancer

   • Jose V. Bagan, Leticia Bagan-Debon

   Pages 47-54

7. Staging of Oral Cancer

   • Ashley Hay, Jatin Shah

   Pages 55-67

8. Pathology of Oral and Oropharyngeal Cancers

   • Saman Warnakulasuriya, Hatsuhiko Maeda, John S. Greenspan

   Pages 69-80

9. Oral Biopsy: Principles and Practice

   • Ranganathan Kannan

   Pages 81-98

10. Diagnostic Adjuncts for Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

    • A. Ross Kerr

    Pages 99-117

11. Detection Methods for Human Papillomavirus (HPV) in Head and Neck Cancers

    • Annemieke van Zante, Richard C. Jordan

    Pages 119-125

12. Diagnostic Imaging of Oral Squamous Cell Carcinoma

    • Michał Studniarek, Paulina Adamska

    Pages 127-140

13. Potentially Malignant Disorders of the Oral Cavity

    • Saman Warnakulasuriya

    Pages 141-158

14. Malignant Transformation of Oral Potentially Malignant Disorders

    • Anura Ariyawardana

    Pages 159-177

15. Molecular and Signaling Pathways During Oral Carcinogenesis

    • Luis Monteiro, Saman Warnakulasuriya

    Pages 179-194

16. Early Diagnosis of Oral Cancer

    • Andrei Barasch, Joel B. Epstein

    Pages 195-200

17. Screening for Oral Cancer

    • Paul M. Speight

    Pages 201-214

18. Lifestyle Interventions for the Prevention of Oral Cancer

    • Pankaj Chaturvedi, Swagnik Chakrabarti, Arjun Gurmeet Singh

    Pages 215-225

19. Chemoprevention in Oral Cancer

    • Holli A. Loomans-Kropp, Eva Szabo

    Pages 227-237

20. General Workup Prior to the Treatment Phase of Oral Cancer

    • Michael Awadallah, Ketan Patel, Deepak Kademani

    Pages 239-252

This comprehensive multidisciplinary book examines all aspects of cancers of the mouth and oropharynx with the aim of equipping advanced students and practitioners in the early stages of specialist training with an up-to-date guide and reference. A multinational team of authors – all experts in the field of oral oncology – provide illuminating contributions on the full range of relevant topics: epidemiology, risk factors, clinical features, staging and prognostic factors, pathology, diagnostic techniques, disease prevention, surgery, radiotherapy, and chemotherapy. Molecular biology, molecular targeted therapies for advanced cases, and future diagnostic and prognostic applications of new technologies also receive careful attention. In providing a wealth of essential information and guidance in a practical format, the book will be a superb asset for senior graduate students in dentistry and specialist trainees in head and neck oncology. It will also be of high value for the many physicians, surgeons, pathologists, dentists, and specialists involved in the prevention, diagnosis, and management of squamous cell carcinomas of the oral cavity and oropharynx.

• Cancers of the mouth and oropharynx
• Risk factors for oral cancer
• Human papillomavirus infection
• Oral cancer detection
• Squamous cell carcinomas of the oral cavity

“All contributors to this textbook brought together their expertise to provide a comprehensive synthesis of the current state of knowledge about oral cancer. The book is aimed at clinicians working in oral medicine, otorhinolaryngology, oncology, head and neck cancer and maxillofacial pathology, especially helping students, residents and surgeons to manage oral cancer patients as comprehensively as possible in routine practice.” (Marian-Vladimir Constantinescu, Stomatology EDU Journal, Vol. 8 (2), 2021)

• Faculty of Dentistry, Oral & Craniofacial Sciences,, King’s College London, London, UK

  Saman Warnakulasuriya

• Department of Orofacial Sciences, Schools of Dentistry and Medicine, University of California San Francisco, San Francisco, USA

  John S. Greenspan

Saman Warnakulasuriya is Professor Emeritus at King’s College London and has been Director of the WHO Collaborating Centre on Oral Cancer since 2005. He is a Past President of the British Dental Association (Metropolitan Branch). Dr. Warnakulasuriya has served on several expert working groups of the International Agency for Research on Cancer (IARC) to evaluate carcinogenicity of substances to humans. He has delivered numerous keynote lectures at international Oral Medicine, Pathology, and Oncology conferences and was on the organizing committee and co-chaired the Global Oral Cancer Forum in New York in 2016. He is a global expert on the epidemiology and risk factors on oral cancer, developed the nomenclature of oral potentially malignant disorders, and has authored more than 250 scientific articles as well as two books, including most recently the Springer book Squamous Cell Carcinoma: Molecular Therapeutic Targets.  He is a member of the editorial board of Oral Oncology and Editor-in-Chief of Translational Research on Oral Oncology (Sage Publishing) and also served as Deputy Editor of Oral Diseases from 1995 to 2005. Dr. Warnakulasuriya has received an OBE from Her Majesty the Queen for services to Medicine and in 2015 was awarded the IADR's Distinguished Scientist Award for Oral Medicine & Pathology. He is a Fellow of King's College London.


John S. Greenspan is Distinguished Professor-Emeritus of Oral Pathology in the Department of Orofacial Sciences and Associate Dean-Emeritus for Global Oral Health in the School of Dentistry at University of California, San Francisco (UCSF). He is also Distinguished Professor-Emeritus of Pathology in the School of Medicine and a leading participant in the UCSF Global Health Sciences Program. He is founding Director of the UCSF Oral AIDS Center and of the UCSF AIDS Specimen Bank. Dr. Greenspan is a Past-President of the American Association for Dental Research (AADR) and of the International Association for Dental Research (IADR). He was founding President of the IADR Global Oral Health Inequalities Research Network (IADR-GOHIRN) and founding Director of the International Sjögren’s Syndrome Registry (SICCA). He is a Fellow of King's College London. He has received the American Association for Dental Research (AADR) Distinguished Scientist Award (2010) and the American Dental Association’s triennial ADA Gold Medal Award for Dental Research (2012). Dr. Greenspan has made major contributions to global HIV research and care. He has published over 300 papers and four books on oral aspects of AIDS, oral pathology, and immunopathology.

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