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Springer Theses

Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocolitica

Authors: Bräuning, Bastian

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  • Nominated as an outstanding Ph.D. thesis by the Technische Universitat Munchen, Garching, Germany
  • Serves as a comprehensive case study of a difficult target protein
  • Focuses on cutting-edge methodology currently in high demand
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書籍の購入

イーブック ¥11,231
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-030-29439-7
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ハードカバー ¥18,251
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-030-29438-0
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この書籍について

This book discusses the decoding of the lytic mechanism of an α-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families. Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Bräuning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts. 

著者について

Bastian Bräuning completed his undergraduate and postgraduate education at the LMU Munich and the Weizmann Institute of Science, Israel. He subsequently pursued doctoral training with Prof. Michael Groll at the TUM Munich, where he mastered biochemical and structural techniques for the analysis of membrane protein complexes. Currently, he is a postdoctoral fellow in Prof. Brenda Schulman’s group at the Max Planck Institute of Biochemistry, where his focus continues to be on challenging membrane protein targets and their regulation. 

Table of contents (5 chapters)

Table of contents (5 chapters)

書籍の購入

イーブック ¥11,231
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-030-29439-7
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: PDF, EPUB
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー ¥18,251
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-030-29438-0
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
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書誌情報

Bibliographic Information
Book Title
Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocolitica
Authors
Series Title
Springer Theses
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
イーブック ISBN
978-3-030-29439-7
DOI
10.1007/978-3-030-29439-7
ハードカバー ISBN
978-3-030-29438-0
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXXI, 86
Topics