Endometrial Gene Expression
An Emerging Paradigm for Reproductive Disorders
Editors: Kwak-Kim, Joanne (Ed.)
Free Preview- Presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders
- Discusses gene expression in cases of repeated implant failure, immune profiling, recurrent pregnancy loss, infection, uterine fibroids, endometriosis and other reproductive and gynecological malignancies
- Ideal for for reproductive endocrinologists, gynecologists, fetal medicine specialists, and all clinicians treating female infertility
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The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions.
This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis.
Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine. - 著者について
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Joanne Kwak-Kim, MD, MPH, Department of Obstetrics and Gynecology, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA.
- Table of contents (13 chapters)
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Endometrial Development and Its Fine Structure
Pages 1-32
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Molecular Biology Techniques for Endometrial Gene Expression: Recent Technological Advances
Pages 33-50
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T Cell-Related Endometrial Gene Expression in Normal and Complicated Pregnancies
Pages 51-66
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Role of Immunoregulatory Cytokine IL-15 in the Endometrium
Pages 67-74
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Endometrial Immune Profiling: An Emerging Paradigm for Reproductive Disorders
Pages 75-89
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Table of contents (13 chapters)
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書誌情報
- Bibliographic Information
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- Book Title
- Endometrial Gene Expression
- Book Subtitle
- An Emerging Paradigm for Reproductive Disorders
- Editors
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- Joanne Kwak-Kim
- Copyright
- 2020
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer Nature Switzerland AG
- イーブック ISBN
- 978-3-030-28584-5
- DOI
- 10.1007/978-3-030-28584-5
- ハードカバー ISBN
- 978-3-030-28583-8
- ソフトカバー ISBN
- 978-3-030-28586-9
- Edition Number
- 1
- Number of Pages
- XIII, 220
- Number of Illustrations
- 15 illustrations in colour
- Topics
