Label-Free Super-Resolution Microscopy

1. Front Matter

   Pages i-xxii

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2. Quantitative Phase Imaging: Principles and Applications

   • Chenfei Hu, Gabriel Popescu

   Pages 1-24

3. Interferometric Scattering (iSCAT) Microscopy and Related Techniques

   • Richard W. Taylor, Vahid Sandoghdar

   Pages 25-65

4. Label-Free, Ultrahigh-Speed, Direct Imaging and Tracking of Bionanoparticles in Live Cells by Using Coherent Brightfield Microscopy

   • Chia-Lung Hsieh

   Pages 67-84

5. Tomographic Diffractive Microscopy: Principles, Implementations, and Applications in Biology

   • Bertrand Simon, Olivier Haeberlé

   Pages 85-112

6. Near-Field Scanning Optical Microscope Combined with Digital Holography for Three-Dimensional Electromagnetic Field Reconstruction

   • Nancy Rahbany, Ignacio Izeddin, Valentina Krachmalnicoff, Rémi Carminati, Gilles Tessier, Yannick De Wilde

   Pages 113-136

7. Absorption-Based Far-Field Label-Free Super-Resolution Microscopy

   • Chen Li, Ji-Xin Cheng

   Pages 137-169

8. Label-Free Pump–Probe Nanoscopy

   • Paolo Bianchini, Giulia Zanini, Alberto Diaspro

   Pages 171-193

9. Super-Resolution Imaging in Raman Microscopy

   • Katsumasa Fujita

   Pages 195-211

10. Usage of Silicon for Label-Free Super-Resolved Imaging

    • Hadar Pinhas, Yossef Danan, Amihai Meiri, Omer Wagner, Asaf Shahmoon, Tali Ilovitsh et al.

    Pages 213-237

11. Super-Resolution Imaging Based on Nonlinear Plasmonic Scattering

    • Tushar C. Jagadale, Shi-Wei Chu

    Pages 239-259

12. Label-Free Super-Resolution Microscopy by Nonlinear Photo-modulated Reflectivity

    • Omer Tzang, Dror Hershkovitz, Ori Cheshnovsky

    Pages 261-287

13. Nonlinear Label-Free Super-Resolution Microscopy Using Structured Illumination

    • Mikko J. Huttunen, Antti Kiviniemi

    Pages 289-312

14. Super-Resolution Microscopy Techniques Based on Plasmonics and Transformation Optics

    • Igor I. Smolyaninov, Vera N. Smolyaninova

    Pages 313-343

15. Label-Free Super-Resolution Imaging with Hyperbolic Materials

    • Emroz Khan, Evgenii Narimanov

    Pages 345-369

16. Super-Resolution Imaging and Microscopy by Dielectric Particle-Lenses

    • Zengbo Wang, Boris Luk’yanchuk

    Pages 371-406

17. Theoretical Foundations of Super-Resolution in Microspherical Nanoscopy

    • Alexey V. Maslov, Vasily N. Astratov

    Pages 407-441

18. Microsphere-Assisted Interference Microscopy

    • Stephane Perrin, Sylvain Lecler, Paul Montgomery

    Pages 443-469

19. Back Matter

    Pages 471-487

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This book presents the advances in super-resolution microscopy in physics and biomedical optics for nanoscale imaging. In the last decade, super-resolved fluorescence imaging has opened new horizons in improving the resolution of optical microscopes far beyond the classical diffraction limit, leading to the Nobel Prize in Chemistry in 2014. This book represents the first comprehensive review of a different type of super-resolved microscopy, which does not rely on using fluorescent markers. Such label-free super-resolution microscopy enables potentially even broader applications in life sciences and nanoscale imaging, but is much more challenging and it is based on different physical concepts and approaches. A unique feature of this book is that it combines insights into mechanisms of label-free super-resolution with a vast range of applications from fast imaging of living cells to inorganic nanostructures. This book can be used by researchers in biological and medical physics. Due to its logically organizational structure, it can be also used as a teaching tool in graduate and upper-division undergraduate-level courses devoted to super-resolved microscopy, nanoscale imaging, microscopy instrumentation, and biomedical imaging.

• Label-free Imaging
• Optical Nanoscopy
• Label-free Super-resolution
• Label-free Nanoscopy
• Super-resolved Fluorescence Microscopy
• Label-free Super-resolution Microscopy
• Superresolution Microscopy
• Microspherical Nanoscopy
• Plasmonics in Super-Resolution Imaging
• Interferometric Scattering Microscopy
• Biological Microscopy

“A thorough and cutting-edge reference of the modern advances in microscopy, the book is valuable reading for researchers and physicists.” (Silvano Donati, Optics & Photonics News, March 19, 2020)

• University of North Carolina at Charlotte, Charlotte, USA

  Vasily Astratov

Vasily N. Astratov has been professor of Physics and Optical Science at the University of North Carolina-Charlotte since 2002. In 1986, he received his Ph.D. degree from the A.F. Ioffe Physical-Technical Institute in Russia. Since joining UNC-Charlotte in 2002, his research has been devoted to a new field of study which he has named "microspherical photonics" to describe the applications of dielectric microspheres in super-resolution microscopy, resonant light forces, photonic nanojets, and photonic molecules. In his lab, he proposed and developed the methods of super-resolution imaging based on using high-index dielectric microspheres immersed in liquids or in elastomeric slabs. His methods are widely used by many groups worldwide for imaging subcellular structures, viruses, and nanoplasmonic structures. He also observed giant light forces exerted on microspheres under resonant conditions with their whispering gallery modes. This observation builds upon earlier pioneering work of Arthur Ashkin and Joseph M. Dziedzic on optical forces exerted on microdroplets. Previously, in the mid-1990s he pioneered studies of synthetic opals as novel three-dimensional photonic crystals for visible light. He has authored and co-authored about 180 research publications and 15 patents which have been cited more than 6000 times.

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