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Atherosclerosis Pathogenesis and Microvascular Dysfunction

  • Book
  • © 2019

Overview

Authors:
  1. Axel Haverich

    1. Hannover Medical School, Hannover, Germany

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    You can also search for this author in PubMed   Google Scholar

  2. Erin Colleen Boyle

    1. Hannover Medical School, Hannover, Germany

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    You can also search for this author in PubMed   Google Scholar

  • Focuses on a unifying concept for the pathogenesis of atherosclerosis

  • Reviews often overlooked evidence on atherosclerosis pathogenesis

  • Features potentially new preventative and therapeutic options for atherosclerosis

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Introduction

    • Axel Haverich, Erin Colleen Boyle
    Pages 1-7

  3. Atherosclerosis Risk Factors

    • Axel Haverich, Erin Colleen Boyle
    Pages 9-45

  4. The Effect of Growth and Aging on the Vascular Architecture

    • Axel Haverich, Erin Colleen Boyle
    Pages 47-54

  5. Incriminating Evidence for the Role of the Microvasculature in Atherosclerosis

    • Axel Haverich, Erin Colleen Boyle
    Pages 55-74

  6. Risk Factors and Prevention in Light of Atherosclerosis Being a Microvascular Disease

    • Axel Haverich, Erin Colleen Boyle
    Pages 75-95

  7. New Ways to Target Vasa Vasorum for the Prevention and Treatment of Atherosclerosis

    • Axel Haverich, Erin Colleen Boyle
    Pages 97-114

  8. Supporting Microvasculature Function

    • Axel Haverich, Erin Colleen Boyle
    Pages 115-127

  9. Back Matter

    Pages 129-130
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Keywords

About this book

This book provides new perspectives on the pathogenesis of atherosclerosis. Chapters cover atherosclerosis risk factors, the effect of growth and aging on vascular architecture, and the crucial role the microvasculature plays in atherosclerosis development. Microvascular dysfunction would explain why the well-known risk factors actually put individuals at higher risk. This pathomechanism would also hold true not only for obstructive atheroma formation but also for aneurysmal dilatation as well as for aortic and peripheral artery dissection. When seen through this lens, novel preventive and therapeutic opportunities can be envisioned.

Atherosclerosis Pathogenesis and Microvascular Dysfunction proposes a single unifying mechanism of atherosclerosis development and describes potential preventative and therapeutic avenues based on this concept. It therefore represents a timely and valuable resource for internal medicine, cardiology, angiology cardiovascular surgeons, pathology clinicians, researchers, trainees, and students.

Authors and Affiliations

  • Hannover Medical School, Hannover, Germany

    Axel Haverich, Erin Colleen Boyle

About the authors

Professor Axel Haverich completed his medical training at the MHH and was appointed head of Cardiovascular Surgery at the University of Kiel in 1993. Since 1996, he has been the head of the Department of Cardiothoracic, Transplantation and Vascular Surgery at MHH. In 1995, he won the prestigious Leibniz Prize from the German Research Foundation (DFG). With this award, he founded the Leibniz Research Laboratories for Biotechnology and Artificial Organs. There, the foundation was laid for many scientific achievements including bioengineered heart valves that grow with the patient and a bioengineered vascular graft for coronary reconstruction based on an autologous fibrin matrix.  His company “CorLife” has provided >250 decellularized heart valves to children and adolescents. Here, two clinical trials have been funded by EU grants.  He has been granted several patents in the field of tissue engineering, such as for a biological vascularized autologous matrix which can replace damaged myocardium. Prof. Haverich served as the coordinator of the Excellence Cluster “From Regenerative Biology to Reconstructive Therapy” from 2006 to 2018. In addition to being the Chairman of the German Society for Thoracic and Cardiovascular Surgery from 2007-2009, he was the president of the German Society of Surgery from 2010 to 2011. He has published over 1000 peer-reviewed papers and has contributed to numerous books.

Dr. Erin Colleen Boyle received her Bachelor of Science (Specialized Honors, Microbiology) from the University of Guelph and her PhD from the Department of Microbiology and Immunology at the University of British Columbia. She was awarded an Alexander von Humboldt Postdoctoral Research Fellowship in 2010. In 2015, Dr. Boyle joined the Department of Cardiothoracic, Transplantation and Vascular Surgery at Hannover Medical School (MHH). She has published numerous primary research and review papers in high-level peer-reviewed journals on the topics of bacterial pathogenesis and atherosclerosis. 


Bibliographic Information

  • Book Title: Atherosclerosis Pathogenesis and Microvascular Dysfunction

  • Authors: Axel Haverich, Erin Colleen Boyle

  • DOI: https://doi.org/10.1007/978-3-030-20245-3

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-20244-6Published: 08 August 2019

  • Softcover ISBN: 978-3-030-20247-7Published: 14 August 2020

  • eBook ISBN: 978-3-030-20245-3Published: 23 July 2019

  • Edition Number: 1

  • Number of Pages: X, 130

  • Number of Illustrations: 3 b/w illustrations, 15 illustrations in colour

  • Topics: Cardiology, Cardiac Surgery, Angiology, Pathology

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