Challenges and Advances in Computational Chemistry and Physics

Structural Bioinformatics: Applications in Preclinical Drug Discovery Process

Editors: Mohan, C. Gopi (Ed.)

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  • Examines successes, risks, and challenges of in-silico drug discovery
     
    Offers integrated case studies, including a discussion of drug resistance with respect to structure-based drug design
     
    Reviews the application of big data in drug discovery

書籍の購入

イーブック n/a
  • ISBN 978-3-030-05282-9
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: PDF, EPUB
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この書籍について

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery.
The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.

著者について

Dr. C. Gopi Mohan is an Associate Professor at the Center for Nanosciences and Molecular Medicine, specializing in the areas of structural bioinformatics, structure-based drug design, protein crystallography, and nanoinformatics. He graduated from Banaras Hindu University with a PhD in Physics and gained experience as a postdoctoral researcher at the Indian Institute of Science, Bangalore (India), as a research officer at the University of Bath (UK) and as an associate researcher at the University Henri Poincare, Nancy (France). Further, he worked as a member of the faculty at the National Institute of Pharmaceutical Education & Research (NIPER), Mohali, Punjab. Dr. Gopi Mohan has published more than 70 research papers in refereed journals and was cited as an internationally recognized expert in the field of Structural Bioinformatics and Chemoinformatics by Synergix Ltd. (UK) founded by Dr. N.C. Cohen, a pioneer of rational drug design. Recently he was awarded the ICMR Senior Biomedical Scientist International Fellowship to visit US laboratories for research collaborations.

書籍の購入

イーブック n/a
  • ISBN 978-3-030-05282-9
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: PDF, EPUB
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
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書誌情報

Bibliographic Information
Book Title
Structural Bioinformatics: Applications in Preclinical Drug Discovery Process
Editors
  • C. Gopi Mohan
Series Title
Challenges and Advances in Computational Chemistry and Physics
Series Volume
27
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
イーブック ISBN
978-3-030-05282-9
DOI
10.1007/978-3-030-05282-9
Series ISSN
2542-4491
Edition Number
1
Number of Pages
XII, 406
Number of Illustrations
27 b/w illustrations, 79 illustrations in colour
Topics