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Springer Theses

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Authors: de Paiva, Raphael

  • Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil 
  • Presents an innovative approach, using gold chemistry to target zinc finger proteins
  • Explores the use of Travelling-Wave Ion Mobility coupled with Mass Spectrometry, and X-ray Absorption Spectroscopy to obtain structural information on the Gold adducts
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書籍の購入

イーブック ¥12,752
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-030-00853-6
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー ¥15,443
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-030-00852-9
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
この書籍について

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Table of contents (6 chapters)

  • Au(I)-Phosphine Series Design

    Ferraz de Paiva, Raphael Enoque

    Pages 3-43

    Preview Buy Chapter ¥3,412
  • Probing the Protein: Ion Mobility Spectrometry

    Ferraz de Paiva, Raphael Enoque

    Pages 45-56

    Preview Buy Chapter ¥3,412
  • Probing Gold: X-Ray Absorption Spectroscopy

    Ferraz de Paiva, Raphael Enoque

    Pages 57-74

    Preview Buy Chapter ¥3,412
  • Probing Cells: Evaluating Cytotoxicity

    Ferraz de Paiva, Raphael Enoque

    Pages 75-90

    Preview Buy Chapter ¥3,412
  • Au(III) Series with κ2C,N and κ2N,N′ Ligands

    Ferraz de Paiva, Raphael Enoque

    Pages 93-130

    Preview Buy Chapter ¥3,412

書籍の購入

イーブック ¥12,752
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-030-00853-6
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー ¥15,443
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-3-030-00852-9
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
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書誌情報

Bibliographic Information
Book Title
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
イーブック ISBN
978-3-030-00853-6
DOI
10.1007/978-3-030-00853-6
ハードカバー ISBN
978-3-030-00852-9
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXXIX, 151
Number of Illustrations and Tables
62 b/w illustrations, 38 illustrations in colour
Topics