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  • © 2017

Cellular Automaton Modeling of Biological Pattern Formation

Characterization, Examples, and Analysis

Birkhäuser
  • An accessible presentation with an interdisciplinary approach to cellular automaton models of biological pattern formation
  • Includes three new chapters on cell migration, tissue development, and cancer dynamics
  • Suggestions for future research topics provided throughout the book
  • Accompanying website, accessible via QR codes within the text, contains simulator for readers to perform their own simulations on several of the models covered

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xxii
  2. General Principles and Models of Pattern Formation

    1. Front Matter

      Pages 1-1
    2. Introduction and Outline

      • Andreas Deutsch, Sabine Dormann
      Pages 3-11
    3. On the Origin of Patterns

      • Andreas Deutsch, Sabine Dormann
      Pages 13-47
    4. Mathematical Modeling of Biological Pattern Formation

      • Andreas Deutsch, Sabine Dormann
      Pages 49-61
  3. Cellular Automaton Modeling

    1. Front Matter

      Pages 63-63
    2. Cellular Automata

      • Andreas Deutsch, Sabine Dormann
      Pages 65-111
  4. Applications

    1. Front Matter

      Pages 113-113
    2. Random Movement

      • Andreas Deutsch, Sabine Dormann
      Pages 115-140
    3. Cell Migration in Heterogeneous Environments

      • Andreas Deutsch, Sabine Dormann
      Pages 141-158
    4. Adhesive Cell Interaction

      • Andreas Deutsch, Sabine Dormann
      Pages 159-183
    5. Alignment and Cellular Swarming

      • Andreas Deutsch, Sabine Dormann
      Pages 185-202
    6. Growth Processes

      • Andreas Deutsch, Sabine Dormann
      Pages 203-217
    7. Pigment Cell Pattern Formation

      • Andreas Deutsch, Sabine Dormann
      Pages 219-230
    8. Tissue Development

      • Andreas Deutsch, Sabine Dormann
      Pages 231-255
    9. Tumor Growth and Invasion

      • Andreas Deutsch, Sabine Dormann
      Pages 257-292
    10. Turing Patterns and Excitable Media

      • Andreas Deutsch, Sabine Dormann
      Pages 293-345
    11. Discussion and Outlook

      • Andreas Deutsch, Sabine Dormann
      Pages 347-361
  5. Back Matter

    Pages 363-464

About this book

This text explores the use of cellular automata in modeling pattern formation in biological systems.  It describes several mathematical modeling approaches utilizing cellular automata that can be used to study the dynamics of interacting cell systems both in simulation and in practice.  New in this edition are chapters covering cell migration, tissue development, and cancer dynamics, as well as updated references and new research topic suggestions that reflect the rapid development of the field.


The book begins with an introduction to pattern-forming principles in biology and the various mathematical modeling techniques that can be used to analyze them.  Cellular automaton models are then discussed in detail for different types of cellular processes and interactions, including random movement, cell migration, adhesive cell interaction, alignment and cellular swarming, growth processes, pigment cell pattern formation, tissue development, tumor growth and invasion, and Turing-type patterns and excitable media.  In the final chapter, the authors critically discuss possibilities and limitations of the cellular automaton approach in modeling various biological applications, along with future research directions.  Suggestions for research projects are provided throughout the book to encourage additional engagement with the material, and an accompanying simulator is available for readers to perform their own simulations on several of the models covered in the text.  QR codes are included within the text for easy access to the simulator.


With its accessible presentation and interdisciplinary approach, Cellular Automaton Modeling of Biological Pattern Formation is suitable for graduate and advanced undergraduate students in mathematical biology, biological modeling, and biological computing.  It will also be a valuable resource for researchers and practitioners in applied mathematics, mathematical biology, computational physics, bioengineering, and computer science.
 
PRAISE FOR THE FIRST EDITION


An ideal guide for someone with a mathematical or physical background to start exploring biological modelling. Importantly, it will also serve as an excellent guide for experienced modellers to innovate and improve their methodologies for analysing simulation results.” —Mathematical Reviews




Reviews

“In this book the authors concentrate on modelling biological pattern formation using cellular automata … . The book would be useful to someone with a mathematical background interested in modelling spatio-temporal dynamics of biological cells at this level of description.” (Carlo Laing, zbMATH 1403.37001, 2019)

Authors and Affiliations

  • Centre for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany

    Andreas Deutsch

  • FB Mathematik/Informatik, Universität Osnabrück, Osnabrück, Germany

    Sabine Dormann

About the authors

Andreas Deutsch, PhD, Department for Innovative Methods of Computing, Center for Information Services and High Performance Computing, Technische Universität Dresden.

Sabine Dormann, PhD, Universität Osnabrück

Bibliographic Information

Buy it now

Buying options

eBook USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 79.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access