Animal Models of Depression

1. Front Matter

   Pages i-xiii

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2. Animal Models

   1. Front Matter

      Pages 1-1

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   2. Basis of Development of Animal Models in Psychiatry: An Overview

      • William T. McKinney

      Pages 3-17

   3. Animal Models: Promises and Problems

      • Conan Kornetsky

      Pages 18-29

   4. Non-Homologous Animal Models of Affective Disorders: Clinical Relevance of Sensitization and Kindling

      • Robert M. Post, Susan R. B. Weiss

      Pages 30-54

3. Developmental Models

   1. Front Matter

      Pages 55-55

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   2. The HPA System and Neuroendocrine Models of Depression

      • Ned H. Kalin

      Pages 57-73

   3. The Use of an Animal Model to Study Post-Stroke Depression

      • Robert G. Robinson

      Pages 74-98

   4. Social Zeitgebers: A Peer Separation Model of Depression in Rats

      • Cindy L. Ehlers, Tamara L. Wall, Stephan P. Wyss, R. Ian Chaplin

      Pages 99-110

   5. Electrophysiology of the Locus Coeruleus: Implications for Stress-Induced Depression

      • Jay M. Weiss, Peter E. Simson

      Pages 111-134

   6. Motor Activity and Antidepressant Drugs: A Proposed Approach to Categorizing Depression Syndromes and Their Animal Models

      • Martin H. Teicher, Natacha I. Barber, Janet M. Lawrence, Ross J. Baldessarini

      Pages 135-161

   7. Anhedonia as an Animal Model of Depression

      • George F. Koob

      Pages 162-183

4. Pharmacologic Models

   1. Front Matter

      Pages 185-185

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   2. Models of Depression Used in the Pharmaceutical Industry

      • James L. Howard, Robert M. Ferris, Barrett R. Cooper, Francis E. Soroko, Ching M. Wang, Gerald T. Pollard

      Pages 187-203

   3. Pharmacological, Biochemical, and Behavioral Analyses of Depression: Animal Models

      • Robert M. Zacharko, Hymie Anisman

      Pages 204-238

   4. Pharmacological Probes in Primate Social Behavior

      • R. Francis Schlemmer Jr., Jennifer E. Young, John M. Davis

      Pages 239-260

   5. The Neuropharmacology of Serotonin and Sleep: an Evaluation

      • John D. Fernstrom, Ross H. Pastel

      Pages 261-280

   6. Epilogue

      • Floyd E. Bloom

      Pages 281-284

5. Back Matter

   Pages 285-295

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Animal models represent experimental investigations developed in one species for the purpose of studying phenomena in another species and provide numerous advantages for preclinical research. They allow scientists greater control and isolation of important experimental variables. Animal models are safe, reproducible strategies by which to evaluate and design new pharma­ cological treatment strategies, while also allowing direct central nervous system intervention to alter the course of the aberrant behavior. Animal models have been developed for a number of mental illnesses; in this particular domain, they hold the promise to shed light on the still obscure etiologies of these illnesses and ultimately to facilitate the development and testing of "cures. " Yet, true models of mental illness are difficult to develop, because mental illness may be a uniquely human phenomenon. It was based on these considerations that the MacArthur Foundation Research Network on the Psychobiology of Depression set out to sponsor a conference to review the status, problems, promises, and relevance of animal models to the clinical conditions of affective disorders. The conference was held in September 1986 and included participants from both within the Network as well as scientists and scholars from various disciplines relevant to the concerns of the conference. After the conference was held, it became clear to the organizers that the material presented could be helpful to a broader field of investigators, since a significant portion of the information has not been presented elsewhere or in the unified context of a monograph.

• behavior
• biology
• central nervous system
• experimental investigations
• nervous system
• pharmacology
• physiology
• psychiatry
• stress

• Department of Neuropharmacology, Research Institute of the Scripps Clinic, La Jolla, USA

  George F. Koob, Cindy L. Ehlers

• Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, USA

  David J. Kupfer

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