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Experimental Neurotoxicology Methods

  • Book
  • © 2021

Overview

Editors:
  1. Jordi Llorens

    1. Departament de Ciències Fisiològiques, Institut de Neurociènces, Universitat de Barcelona, Hospitalet de Llobregat, Catalunya, Spain

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  2. Marta Barenys

    1. Departament de Farmacologia, Toxicologia i Química Terapèutica, Universitat de Barcelona, Barcelona, Catalunya, Spain

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts.

Part of the book series: Neuromethods (NM, volume 172)

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Table of contents (23 protocols)

  1. Front Matter

    Pages i-xvi
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  2. Cytological and Histological Evaluation in Rodents

    1. Front Matter

      Pages 1-1
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    2. Amino-Cupric-Silver (A-Cu-Ag) Staining to Detect Neuronal Degeneration in the Mouse Brain: The de Olmos Technique

      • Rosario Moratalla, Adrián Sanz-Magro, Noelia Granado
      Pages 3-19

    3. Assessment of Auditory Hair Cell Loss by Cytocochleograms

      • Aurélie Thomas, Thomas Venet, Benoît Pouyatos
      Pages 21-34

    4. Evaluation of Cellular and Molecular Pathology in the Rodent Vestibular Sensory Epithelia by Immunofluorescent Staining and Confocal Microscopy

      • Alberto F. Maroto, Erin A. Greguske, Alejandro Barrallo-Gimeno, Jordi Llorens
      Pages 35-50

    5. Morphometric Analysis of Axons and Dendrites as a Tool for Assessing Neurotoxicity

      • Rhianna K. Morgan, Martin Schmuck, Ana Cristina Grodzki, Donald A. Bruun, Lauren E. Matelski, Pamela J. Lein
      Pages 51-87

  3. Physiological Evaluation in Rodents

    1. Front Matter

      Pages 89-89
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    2. DPOAEs for the Assessment of Noise- or Toxicant-Induced Cochlear Damage in the Rat

      • Thomas Venet, Aurélie Thomas, Ludivine Wathier, Benoît Pouyatos
      Pages 91-108

    3. Use of Visual Evoked Potentials to Assess Deficits in Contrast Sensitivity in Rats Following Neurotoxicant Exposures

      • William K. Boyes
      Pages 109-132

    4. Electrophysiological Assessments in Peripheral Nerves and Spinal Cord in Rodent Models of Chemotherapy-Induced Painful Peripheral Neuropathy

      • Susanna Park, Cynthia L. Renn, Justin G. Lees, Susan G. Dorsey, Guido Cavaletti, Valentina A. Carozzi
      Pages 133-161

  4. Behavioral Evaluation in Rodents

    1. Front Matter

      Pages 163-163
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    2. The Functional Observation Battery: Utility in Safety Assessment of New Molecular Entities

      • David V. Gauvin
      Pages 165-198

    3. Behavioral Assessment of Vestibular Dysfunction in Rats

      • Alberto F. Maroto, Erin A. Greguske, Meritxell Deulofeu, Pere Boadas-Vaello, Jordi Llorens
      Pages 199-215

    4. Assessment of Olfactory Toxicity in Rodents

      • David C. Dorman, Melanie L. Foster
      Pages 217-237

    5. Assessment of Neurotoxicant-Induced Changes in Behavior : Issues Related to Interpretation of Outcomes and Experimental Design

      • Deborah A. Cory-Slechta, Katherine Harvey, Marissa Sobolewski
      Pages 239-263

  6. Alternative Model Organism-Based Methods

    1. Front Matter

      Pages 325-325
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Keywords

About this book

This volume explores the latest methods that seek to address the vital questions being asked in neurotoxicology research. The chapters in this book cover a variety of available methods from the molecular level to the organism level, and both in vitro and in vivo approaches, including alternative model organisms. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.


Cutting-edge and authoritative, Experimental Neurotoxicology Methods is a valuable resource for both young and experienced researchers who are looking for guidance to implement these methods in their laboratories or for understanding the data generated through these techniques.


Editors and Affiliations

  • Departament de Ciències Fisiològiques, Institut de Neurociènces, Universitat de Barcelona, Hospitalet de Llobregat, Catalunya, Spain

    Jordi Llorens

  • Departament de Farmacologia, Toxicologia i Química Terapèutica, Universitat de Barcelona, Barcelona, Catalunya, Spain

    Marta Barenys

Bibliographic Information

  • Book Title: Experimental Neurotoxicology Methods

  • Editors: Jordi Llorens, Marta Barenys

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-0716-1637-6

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1636-9Published: 24 July 2021

  • Softcover ISBN: 978-1-0716-1639-0Published: 25 July 2022

  • eBook ISBN: 978-1-0716-1637-6Published: 23 July 2021

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XVI, 491

  • Number of Illustrations: 27 b/w illustrations, 85 illustrations in colour

  • Topics: Neurosciences, Biomedicine, general

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