Editors:
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 2315)
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Table of contents (17 protocols)
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Front Matter
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Introduction
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Front Matter
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Structure Prediction and Oligomerization
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Front Matter
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Coarse-Grained and Atomistic MD Simulations
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Front Matter
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Membrane Permeability and Transport
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Front Matter
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About this book
This volume provides an overview of the current successes as well as pitfalls and caveats that are hindering the design of membrane proteins. Divided into six parts, chapters detail membrane transporter, FoldX force field, protein stability, G-Protein Coupled Receptors (GPCR) structures, transmembrane helices, membrane molecular dynamics (MD) simulations, pH-dependent protonation states, membrane permeability, and passive transport. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Computational Design of Membrane Proteins aims to ensure successful results in the further study of this vital field.
Chapter 4 is available open access under a Creative CommonsAttribution 4.0 International License via link.springer.com.
Editors and Affiliations
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Department of Life Sciences, University of Coimbra, Coimbra, Portugal
Irina S. Moreira
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BioISI, University of Lisboa, Lisboa, Portugal
Miguel Machuqueiro
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Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
Joana Mourão
Bibliographic Information
Book Title: Computational Design of Membrane Proteins
Editors: Irina S. Moreira, Miguel Machuqueiro, Joana Mourão
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-0716-1468-6
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021
Hardcover ISBN: 978-1-0716-1467-9Published: 25 July 2021
Softcover ISBN: 978-1-0716-1470-9Published: 26 July 2022
eBook ISBN: 978-1-0716-1468-6Published: 24 July 2021
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XI, 290
Number of Illustrations: 4 b/w illustrations, 53 illustrations in colour
Topics: Protein Science