Gut Microbiome and Metabolic Disorders: a topical collection
Editor: Massimo Federici
Disorders of the gut microbiome have been connected to a multitude of adverse conditions, including obesity, type 2 diabetes, cardiovascular diseases, inflammatory bowel diseases, anxiety, autism, allergies, and autoimmune diseases. Despite the overall skepticism, in the past decade, growing evidence has shown that the composition of the gut microbiota and its activity might be associated with perturbation of the nutrients absorption and the onset of inflammation in the host. Therefore, the gut microbiome might “coordinate” individual responses to environmental factors to explain penetrance of certain disorders beyond genetics.It has been also recently hypothesized that loss of the microbiota-host equilibrium may explain the onset of “pre-disease” states (pre-diabetes, pre-hypertension, etc.) and thus contribute to the explosive development of chronic diseases such as inflammatory bowel disease, obesity, and other metabolic/inflammatory disorders. The topical collection welcomes studies dedicated to the gut microbiome and its impact on metabolic disorders.