MAASC/ISOO Mucositis Guidelines 2019 Update: Part 2

Developed by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO), this set of articles is part of the MASCC/ISOO clinical practice guidelines for the management of mucositis.

This set focuses on the following topics: growth factors and cytokines [Logan et al.], antimicrobials, mucosal coating agents, anesthetics, and analgesics [Saunders et al.], cryotherapy [Correa et al.], and natural and miscellaneous agents [Yarom et al.]. For each of these topics, the literature was reviewed systematically, and new evidence was merged with the evidence published in the previous guideline update [Lalla et al.]. All the data was used to define the up-to-date level of evidence (LoE) and a guideline category: Recommendation, Suggestion, or No Guideline Possible.

For all four topics, new evidence was identified, including evidence for interventions for which guidelines were established in the previous update. The new evidence resulted in three scenarios: (1) the LoE and the guideline statement remained unchanged; (2) the LoE was enhanced and the guideline statement remained unchanged; (3) reversal of the guideline statement. In the section presenting Natural and Miscellaneous Agents, evidence for numerous new agents was identified, and 3 new guidelines were established.

The MASCC/ISOO mucositis guidelines 2019: the second set of articles and future directions. Sharon Elad

Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines. M Elvira P Correa, Karis Kin Fong Cheng, Karen Chiang, et al.

Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines — part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents. Noam Yarom, Allan Hovan, Paolo Bossi, et al.

Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients and clinical practice guidelines. Deborah P. Saunders, Tanya Rouleau, Karis Cheng, et al.

Systematic review of growth factors and cytokines for the management of oral mucositis in cancer patients and clinical practice guidelines. Richard M. Logan, Abdul Rahman Al-Azri, Paolo Bossi, et al.