Virchows Archiv - Virtual Collection 2021 : Uropathology
In recent years, morphological and molecular data have provided a new conceptual framework and updated terminology for the pathologist’s diagnostic approach of kidney and bladder cancer.
In this virtual collection we highlight papers from Virchows Archiv and Modern Pathology which focus on the most recent pathological criteria, potential new biomarkers and advances in the molecular approach for an accurate clinically-relevant classification of kidney and bladder cancer.
Courtesy of Virchows Archiv
“High-grade oncocytic renal tumor”: morphologic, immunohistochemical, and molecular genetic study of 14 cases (this opens in a new tab) He, H., Trpkov, K., Martinek, P. et al.
“Mucin”-secreting papillary renal cell carcinoma: clinicopathological, immunohistochemical, and molecular genetic analysis of seven cases (this opens in a new tab) Pivovarcikova, K., Peckova, K., Martinek, P. et al.
Morphological, immunohistochemical, and chromosomal analysis of multicystic chromophobe renal cell carcinoma, an architecturally unusual challenging variant (this opens in a new tab) Foix, M.P., Dunatov, A., Martinek, P. et al.
Reduced immunohistochemical PTEN staining is associated with higher progression rate and recurrence episodes in non-invasive low-grade papillary urothelial carcinoma of the bladder (this opens in a new tab) Kulac, I., Arslankoz, S., Netto, G.J. et al.
Metastatic breast carcinoma to the urinary bladder—a report of 11 cases including a tumor to tumor metastasis (this opens in a new tab) Wang, G., Zhou, C., Conklin, C. et al.
Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme (this opens in a new tab) Ohashi, R., Martignoni, G., Hartmann, A. et al.
An autopsy case of amyloid tubulopathy exhibiting characteristic spheroid-type deposition (this opens in a new tab) Ichimata, S., Hata, Y., Abe, R. et al.
Courtesy of Modern Pathology
Distinctive mechanisms underlie the loss of SMARCB1 protein expression in renal medullary carcinoma: morphologic and molecular analysis of 20 cases (this opens in a new tab) Jia, L., Carlo, M.I., Khan, H. et al.
Tubulocystic renal cell carcinoma: a distinct clinicopathologic entity with a characteristic genomic profile (this opens in a new tab) Sarungbam, J., Mehra, R., Tomlins, S.A. et al.
Recurrent KRAS mutations in papillary renal neoplasm with reverse polarity (this opens in a new tab) Al-Obaidy, K.I., Eble, J.N., Nassiri, M. et al.
ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217 (this opens in a new tab) Kuroda, N., Trpkov, K., Gao, Y. et al.
Ki-67 is an independent predictor of prostate cancer death in routine needle biopsy samples: proving utility for routine assessments (this opens in a new tab) Kammerer-Jacquet, SF., Ahmad, A., Møller, H. et al.
HNF1β is a sensitive and specific novel marker for yolk sac tumor: a tissue microarray analysis of 601 testicular germ cell tumors (this opens in a new tab) Gallo, A., Fankhauser, C., Hermanns, T. et al.
Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia (this opens in a new tab) Trpkov, K., Williamson, S.R., Gill, A.J. et al.
Pseudosarcomatous myofibroblastic proliferations of the urinary bladder are neoplasms characterized by recurrent FN1–ALK fusions (this opens in a new tab) Acosta, A.M., Demicco, E.G., Dal Cin, P. et al.
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia (this opens in a new tab) Trpkov, K., Hes, O., Williamson, S.R. et al.
MET alterations in biphasic squamoid alveolar papillary renal cell carcinomas and clinicopathological features (this opens in a new tab) Denize, T., Just, P.A., Sibony, M. et al.
Cover Image from "High-grade oncocytic renal tumor”: morphologic, immunohistochemical, and molecular genetic study of 14 cases. He, H., Trpkov, K., Martinek, P. et al. 2018.