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European Journal of Nuclear Medicine and Molecular Imaging - Featured content on State-of-the-Art of NMMI in China

State-of-the-Art of Nuclear Medicine and Molecular Imaging in China 

Guest Editors: Xiaoli Lan, Li Huo, Shuren Li, Jing Wang, Weibo Cai

Advanced Imaging Analysis 

Shi, Z., Zhang, Z., Liu, Z. et al. 
Methodological quality of machine learning-based quantitative imaging analysis studies in esophageal cancer: a systematic review of clinical outcome prediction after concurrent chemoradiotherapy.
Eur J Nucl Med Mol Imaging (2021). https://doi.org/10.1007/s00259-021-05658-9 (this opens in a new tab)

Huang, Z., Wu, Y., Fu, F. et al
Parametric image generation with the uEXPLORER total-body PET/CT system through deep learning.
Eur J Nucl Med Mol Imaging (2022).  https://doi.org/10.1007/s00259-022-05731-x (this opens in a new tab)

Liu, G., Yu, H., Shi, D. et al.
Short-time total-body dynamic PET imaging performance in quantifying the kinetic metrics of 18F-FDG in healthy volunteers.
Eur J Nucl Med Mol Imaging (2021). https://doi.org/10.1007/s00259-021-05500-2 (this opens in a new tab)

Zhang, Y., Hu, P., He, Y. et al.
Ultrafast 30-s total-body PET/CT scan: a preliminary study.
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05838-1 (this opens in a new tab)

Miscellanea

Hu, J., Li, H., Sui, Y. et al.
Current status and future perspective of radiopharmaceuticals in China.
Eur J Nucl Med Mol Imaging (2021). https://doi.org/10.1007/s00259-021-05615-6 (this opens in a new tab)

Zhang, Z., He, K., Chi, C. et al. 
Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China.
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05730-y (this opens in a new tab)

Song, W., Song, Y., Li, Q. et al. 
Advances in aptamer-based nuclear imaging. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05782-0 (this opens in a new tab)

Li, P., He, X., Li, Y. et al. 
Recent advances in aggregation-induced emission luminogens in photoacoustic imaging. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05726-8 (this opens in a new tab)

Preclinical Imaging

Wang, X., Zhou, M., Chen, B. et al. 
Preclinical and exploratory human studies of novel 68Ga-labeled D-peptide antagonist for PET imaging of TIGIT expression in cancers.
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-021-05672-x (this opens in a new tab)

Fu, Z., Lin, Q., Xu, Z. et al. 
P2X7 receptor-specific radioligand 18F-FTTM for atherosclerotic plaque PET imaging. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05689-w (this opens in a new tab)

Wen, X., Shi, C., Yang, L. et al.
A radioiodinated FR-β-targeted tracer with improved pharmacokinetics through modification with an albumin binder for imaging of macrophages in AS and NAFL. 
Eur J Nucl Med Mol Imaging 49, 503–516 (2022). https://doi.org/10.1007/s00259-021-05447-4 (this opens in a new tab)

Zhang, Y., Cheng, H., Chen, H. et al.
A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. 
Eur J Nucl Med Mol Imaging (2021). https://doi.org/10.1007/s00259-021-05654-z (this opens in a new tab)

Xu, J., Cai, F., Luo, Z. et al. 
Design, synthesis, and preclinical evaluation of a novel bifunctional macrocyclic chelator for theranostics of cancers. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05750-8 (this opens in a new tab)

Hu, G., Zhu, W., Liu, Y. et al. 
Development and comparison of three 89Zr-labeled anti-CLDN18.2 antibodies to noninvasively evaluate CLDN18.2 expression in gastric cancer: a preclinical study. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05739-3 (this opens in a new tab)

Huang, L., Fang, J., Hong, S. et al. 
MicroPET imaging of bacterial infection with nitroreductase-specific responsive 18F-labelled nitrogen mustard analogues. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05710-2 (this opens in a new tab)

Hou, Z., Zhou, M., Ma, Y. et al. 
Size-changeable nanoprobes for the combined radiotherapy and photodynamic therapy of tumor. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05830-9 (this opens in a new tab)

Qian, R., Jing, B., Jiang, D. et al. 
Multi-antitumor therapy and synchronous imaging monitoring based on exosome. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05696-x (this opens in a new tab)

An, S., Zhang, D., Zhang, Y. et al. 
GPC3-targeted immunoPET imaging of hepatocellular carcinomas. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05723-x (this opens in a new tab)

Xu, H., Wang, Y., Zhang, J. et al. 
A self-triggered radioligand therapy agent for fluorescence imaging of the treatment response in prostate cancer. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05743-7 (this opens in a new tab)

Li, H., Ye, S., Li Li et al. 
18F- or 177Lu-labeled bivalent ligand of fibroblast activation protein with high tumor uptake and retention. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05757-1 (this opens in a new tab)

Yu, F., Li, M., Wang, Q. et al. 
Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05764-2 (this opens in a new tab)

Wang, G., Li, W., Shi, G. et al. 
Sensitive and specific detection of breast cancer lymph node metastasis through dual-modality magnetic particle imaging and fluorescence molecular imaging: a preclinical evaluation. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05834-5 (this opens in a new tab)

Translational Research

Qian, R., Jing, B., Jiang, D. et al. 
Multi-antitumor therapy and synchronous imaging monitoring based on exosome. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05696-x (this opens in a new tab)

Wang, S., Zhou, X., Xu, X. et al. 
Clinical translational evaluation of Al18F-NOTA-FAPI for fibroblast activation protein-targeted tumour imaging. 
Eur J Nucl Med Mol Imaging 48, 4259–4271 (2021). https://doi.org/10.1007/s00259-021-05470-5 (this opens in a new tab)

Liu, T., Liu, C., Zhang, Z. et al. 
64Cu-PSMA-BCH: a new radiotracer for delayed PET imaging of prostate cancer. 
Eur J Nucl Med Mol Imaging 48, 4508–4516 (2021). https://doi.org/10.1007/s00259-021-05426-9 (this opens in a new tab)

Luo, H., Yang, C., Kuang, D. et al. 
Visualizing dynamic changes in PD-L1 expression in non-small cell lung carcinoma with radiolabeled recombinant human PD-1. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05680-5 (this opens in a new tab)

Lu, D., Zhou, H., Li, N. et al. 
Galectin expression detected by 68Ga-galectracer PET as a predictive biomarker of radiotherapy resistance. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05711-1 (this opens in a new tab)

Wei, Y., Zheng, J., Ma, L. et al. 
[18F]AlF-NOTA-FAPI-04: FAP-targeting specificity, biodistribution, and PET/CT imaging of various cancers. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05758-0 (this opens in a new tab)

Wu, Y., Zhang, X., Zhou, H. et al. 
Synthesis, preclinical evaluation, and first-in-human study of Al18F-PSMA-Q for prostate cancer imaging. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05775-z (this opens in a new tab)

Cardiology

Xie, B., Wang, J., Xi, XY. et al. 
Fibroblast activation protein imaging in reperfused ST-elevation myocardial infarction: comparison with cardiac magnetic resonance imaging. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-021-05674-9 (this opens in a new tab)

Zhang, Z., Chen, X., Wan, Q. et al. 
A two-stage cardiac PET and late gadolinium enhancement MRI co-registration method for improved assessment of non-ischemic cardiomyopathies using integrated PET/MR. 
Eur J Nucl Med Mol Imaging 49, 2199–2208 (2022). https://doi.org/10.1007/s00259-022-05681-4 (this opens in a new tab)

Neurology

Zhao, Y., Wu, P., Wu, J. et al. 
Decoding the dopamine transporter imaging for the differential diagnosis of parkinsonism using deep learning. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05804-x (this opens in a new tab)

Wang, J., Yang, H., Cui, B. et al. 
Effects of MRI protocols on brain FDG uptake in simultaneous PET/MR imaging. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05703-1 (this opens in a new tab)

Oncology

Qiu, DX., Li, J., Zhang, JW. et al. 
Dual-tracer PET/CT-targeted, mpMRI-targeted, systematic biopsy, and combined biopsy for the diagnosis of prostate cancer: a pilot study. 
Eur J Nucl Med Mol Imaging (2021). https://doi.org/10.1007/s00259-021-05636-1 (this opens in a new tab)

Hu, K., Wang, L., Wu, H. et al. 
[18F]FAPI-42 PET imaging in cancer patients: optimal acquisition time, biodistribution, and comparison with [68Ga]Ga-FAPI-04. 
Eur J Nucl Med Mol Imaging (2021). https://doi.org/10.1007/s00259-021-05646-z (this opens in a new tab)

Li, M., Younis, M.H., Zhang, Y. et al. 
Clinical summary of fibroblast activation protein inhibitor-based radiopharmaceuticals: cancer and beyond. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05706-y (this opens in a new tab)

Wu, J., Tian, J., Zhang, Y. et al. 
18F-Alfatide II for the evaluation of axillary lymph nodes in breast cancer patients: comparison with 18F-FDG. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-021-05333-z (this opens in a new tab)

Zhang, Z., Jia, G., Pan, G. et al. 
Comparison of the diagnostic efficacy of 68 Ga-FAPI-04 PET/MR and 18F-FDG PET/CT in patients with pancreatic cancer. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05729-5 (this opens in a new tab)

Gu, B., Liu, X., Wang, S. et al. 
Head-to-head evaluation of [18F]FDG and [68 Ga]Ga-DOTA-FAPI-04 PET/CT in recurrent soft tissue sarcoma. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05700-4 (this opens in a new tab)

Jiang, C., Li, A., Teng, Y. et al. 
Optimal PET-based radiomic signature construction based on the cross-combination method for predicting the survival of patients with diffuse large B-cell lymphoma. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05717-9 (this opens in a new tab)

Sun, K., Shi, L., Qiu, J. et al. 
Multi-phase contrast-enhanced magnetic resonance image-based radiomics-combined machine learning reveals microscopic ultra-early hepatocellular carcinoma lesions. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05742-8 (this opens in a new tab)

He, K., Li, P., Zhang, Z. et al. 
Intraoperative near-infrared fluorescence imaging can identify pelvic nerves in patients with cervical cancer in real time during radical hysterectomy.
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05686-z (this opens in a new tab)

Chen, X., Liu, X., Wang, L. et al. 
Expression of fibroblast activation protein in lung cancer and its correlation with tumor glucose metabolism and histopathology. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05754-4 (this opens in a new tab)

Yang, G., Nie, P., Yan, L. et al. 
The radiomics-based tumor heterogeneity adds incremental value to the existing prognostic models for predicting outcome in localized clear cell renal cell carcinoma: a multicenter study. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05773-1 (this opens in a new tab)

Lin, R., Lin, Z., Chen, Z. et al. 
[68Ga]Ga-DOTA-FAPI-04 PET/CT in the evaluation of gastric cancer: comparison with [18F]FDG PET/CT. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05799-5 (this opens in a new tab)

Zhao, X., Liang, YJ., Zhang, X. et al. 
Deep learning signatures reveal multiscale intratumor heterogeneity associated with biological functions and survival in recurrent nasopharyngeal carcinoma. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05793-x (this opens in a new tab)

Zhou, X., Wang, S., Xu, X. et al. 
Higher accuracy of [68 Ga]Ga-DOTA-FAPI-04 PET/CT comparing with 2-[18F]FDG PET/CT in clinical staging of NSCLC. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05818-5 (this opens in a new tab)

Sun, T., Wang, Z., Wu, Y. et al. 
Identifying the individual metabolic abnormities from a systemic perspective using whole-body PET imaging. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05832-7 (this opens in a new tab)

Errata

Zhang, Y., Cheng, H., Chen, H. et al. 
Correction to: A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05813-w (this opens in a new tab)

Li, M., Younis, M.H., Zhang, Y. et al. 
Correction to: Clinical summary of fibroblast activation protein inhibitor‑based radiopharmaceuticals: cancer and beyond. 
Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05823-8 (this opens in a new tab)

Articles already pubished in Issue 7, 2022

Wen, X., Shi, C., Yang, L. et al. 
A radioiodinated FR-β-targeted tracer with improved pharmacokinetics through modification with an albumin binder for imaging of macrophages in AS and NAFL. 
Eur J Nucl Med Mol Imaging 49, 503–516 (2022). https://doi.org/10.1007/s00259-021-05447-4 (this opens in a new tab)

Wang, S., Zhou, X., Xu, X. et al. 
Clinical translational evaluation of Al18F-NOTA-FAPI for fibroblast activation protein-targeted tumour imaging. 
Eur J Nucl Med Mol Imaging 48, 4259–4271 (2021). https://doi.org/10.1007/s00259-021-05470-5 (this opens in a new tab)

Liu, T., Liu, C., Zhang, Z. et al. 
64Cu-PSMA-BCH: a new radiotracer for delayed PET imaging of prostate cancer. 
Eur J Nucl Med Mol Imaging 48, 4508–4516 (2021). https://doi.org/10.1007/s00259-021-05426-9 (this opens in a new tab)

Zhang, Z., Chen, X., Wan, Q. et al. 
A two-stage cardiac PET and late gadolinium enhancement MRI co-registration method for improved assessment of non-ischemic cardiomyopathies using integrated PET/MR. 
Eur J Nucl Med Mol Imaging 49, 2199–2208 (2022). https://doi.org/10.1007/s00259-022-05681-4 (this opens in a new tab)


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