Immunogenetics - Highlighted Articles

Editor’s Choice: Free Reading (this opens in a new tab) on TIR domains

The study of Toshchakov and Neuwald analyses Toll-Interleukin-1R Resistance domains (TIRs) at a large scale.  The authors use a series of statistical approaches to identify 26414 TIRs in publicly available protein sequence databases, and then hierarchically classify them based on group-specific residue patterns.  The functionality of the group-defining pattern residues is reviewed in the light of available biochemical and structural data.  One example of identified patterns, shown in the accompanying image, presents the evolutionary conserved, TIRAP/Mal-specific residues involved in the assembly of TLR signaling complexes.  
URL: https://link.springer.com/article/10.1007/s00251-020-01157-7 (this opens in a new tab)