Skeletal Muscle

Call for Papers: Cellular microenvironments in skeletal muscle homeostasis, regeneration, and disease

Skeletal Muscle is calling for submissions to our new Collection on Cellular microenvironments in skeletal muscle homeostasis, regeneration, and disease. This Collection focuses on signaling interactions, changes during muscle regeneration, perturbations in aging and disease, and the biomechanical cues involved in muscle homeostasis and repair.

Call for Papers: Skeletal Muscle Fiber Heterogeneity

Skeletal Muscle is calling for submissions to our new Collection on Skeletal Muscle Fiber Heterogeneity. This Collection aims to explore the diverse facets of muscle fiber heterogeneity.

Call for Papers: In Vitro Models of Skeletal Muscle

Skeletal Muscle is calling for submissions to our new Collection on In Vitro Models of Skeletal Muscle. This Collection aims to showcase advancements in in vitro modeling of skeletal muscle physiology and pathology.

Featured Article: Zebrafish and cellular models of SELENON-Congenital myopathy exhibit novel embryonic and metabolic phenotypes

SELENON-Congenital Myopathy (SELENON-CM) is a rare congenital myopathy caused by mutations of the SELENON gene characterized by axial muscle weakness and progressive respiratory insufficiency. Muscle histopathology may be non-specific, but commonly includes multiminicores or a dystrophic pattern. The SELENON gene encodes selenoprotein N (SelN), a selenocysteine-containing redox enzyme located in the endo/sarcoplasmic reticulum membrane where it colocalizes with mitochondria-associated membranes. However, the molecular mechanism(s) by which SelN deficiency cause SELENON-CM remain poorly understood. A hurdle is the lack of cellular and animal models that show easily assayable phenotypes.

Authors: Pamela Barraza-Flores, Behzad Moghadaszadeh, Won Lee, Biju Isaac, Liang Sun, Emily T. Hickey, Shira Rockowitz, Piotr Sliz & Alan H. Beggs

Published: 15 March 2025