Drug Delivery and Translational Research - Featured articles, December 2020 issue
Read the best article from the December 2020 issue:
Convention-enhanced delivery (CED) is developed to infuse drugs directly into the brain using a catheter with a continuous positive pressure, thus overcoming the limitations of intravascular delivery such as blood-brain barrier. However, tissue distribution and retention of the infused drugs in the brain are significantly hindered by microenvironmental factors of the brain such as the extracellular matrix and lymphatic drainage system. In this work, we precisely engineered liposomal formulations to improve the therapeutic efficacy of CED for the treatment of glioblastoma. We found that PEGylated liposomal formulations incorporated with cationic lipids at the proper molar ratio exhibited specific cellular uptake in the glioblastoma cells in vitro, and efficient tissue distribution and retention in the brain tumor after CED. We believe that liposomal drugs engineered based on the biophysical properties of disease microenvironments will be widely used to improve the therapeutic efficacy of CED for the treatment of brain diseases.
This paper was selected by the Guest Editors and Main Editors as the best paper from the 22nd International Symposium on Microencapsulation. This article will be Free-to-Access until 2 January, 2021.
The Guest Editors and Main Editors also selected the following two featured papers:
- Intranasal administration of budesonide-loaded nanocapsule microagglomerates as an innovative strategy for asthma treatment (this opens in a new tab)
- Zein-based nanoparticles for the oral delivery of insulin (this opens in a new tab)
These articles will also be Free-to-Access until 2 January, 2021.