Drug Delivery and Translational Research - Featured Article: August 2020

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Summary: Sorafenib, a first-line drug for advanced liver cancer, exhibits low and inconsistent oral bioavailability due primarily to its poor aqueous solubility, extensive first-pass metabolism and high level drug efflux by P-gp. Administration of sorafenib at high doses, necessary for meaningful therapeutic action, increases the intensity of associated side effects. Therefore, efforts were undertaken to develop supersaturated Type-III self-emulsifying delivery system for efficient and safe delivery of sorafenib, capitalizing the ease of preparation, biocompatibility, biodegradability, ability to bypass first-pass metabolism, high drug loading capacity, colloidal stability for long-term storage, and excellent scalability. Promising outcomes in diverse experimental studies corroborate immense potential of the system in augmenting the chemotherapeutic efficacy of sorafenib while minimizing safety concern.

This paper was selected as the best paper of the August 2020 issue by the Guest Editors and Main Editors.  This article will be Free-to-Access until 24 September, 2020.