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Here are the ten most cited papers published from 2018-2019 in Drug Delivery and Translational Research.  Together they represent high-quality research published in DDTR on a wide range of topics as judged and cited by your peers. Discover them now!

Read the featured article from the October 2020 issue!

Summary: The effect of local anesthetics, particularly those which are hydrophilic, such as tetrodotoxin (TTX), is impeded by tissue barriers that restrict access to individual nerve cells. Insonation has been used to disrupt vascular and cell membranes, which can facilitate transport of substances across biological barriers. Using an in vivo model of local anesthetic delivery, we investigated the effect of acoustic intensity on insonation-mediated delivery of local anesthetics to the peripheral nerve. We found that insonation at acoustic intensity greater than 0.5 W/cm² was capable of enhancing TTX delivery to the peripheral nerve but not bupivacaine, a more hydrophobic local anesthetic. The finding here suggests that the effect of insonation on local drug delivery to the peripheral nerve depends on the hydrophilic/hydrophobic balance of the drug.

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Summary: Sorafenib, a first-line drug for advanced liver cancer, exhibits low and inconsistent oral bioavailability due primarily to its poor aqueous solubility, extensive first-pass metabolism and high level drug efflux by P-gp. Administration of sorafenib at high doses, necessary for meaningful therapeutic action, increases the intensity of associated side effects. Therefore, efforts were undertaken to develop supersaturated Type-III self-emulsifying delivery system for efficient and safe delivery of sorafenib, capitalizing the ease of preparation, biocompatibility, biodegradability, ability to bypass first-pass metabolism, high drug loading capacity, colloidal stability for long-term storage, and excellent scalability. Promising outcomes in diverse experimental studies corroborate immense potential of the system in augmenting the chemotherapeutic efficacy of sorafenib while minimizing safety concern.

This paper was selected as the best paper of the August 2020 issue by the Guest Editors and Main Editors. This article will be Free-to-Access until 24 September, 2020.