The Nucleus - Thematic Issue 2025: Breakthroughs in Genetics and Genomics Research in the First 25 years of The New Millenia

Topic Editors:

Sandipan Brahma, PhD.
Assistant Professor
Department of Genetics, Cell Biology & Anatomy
985805 Nebraska Medical Center
Omaha, NE 68198

Somnath Paul, PhD.
Staff Scientist
Department of Pathology and Immunology
Washington University
Saint Louis, MO

As genes evolved over millions of years as life transformed from single celled organisms to multi-cellular forms; research has evolved and expanded its understanding of the science behind it all. This has accelerated in the past century and has spearheaded into the new millennia. Several innovations in the first twenty five years into this new millennia have enabled researchers, especially in the field of molecular biology to bring their science from the board to the bench to bedside. To date, more than 350 organism’s genomes, including humans, have been either completely or partially sequenced and annotated, or are ongoing. The first genome to be sequenced was that of the bacteriophage MS2 in 1976. Meteoric advancement of sequencing technology and concomitant reduced cost increased high throughput outcomes resulting in decoding higher and more complex genomes and biological processes. Since 2000, the list of annotated genomes include critical organisms used as model systems like Arabidopsis thaliana (2000), Drosophila melanogaster (2000), Homo sapiens sapien (2001), Mus musculus (2002), Oryza sativa (2002) and more recently, Danio rerio (2013) to name a few. They create the necessary references for researchers trying to investigate the molecular aspects of development, propagation, evolution, or diseases of and by the organisms. In this special issue, we look forward to publishing research and review articles focusing on genetics and genomics research powered by technological and scientific advancements around the past 25 years. Areas with respect to any life forms that are to be covered in this special issue may include, but are not limited to:

1. Applications and utility of sequences in basic and clinical research. 
2. Meta-analysis of population genetics pertaining to diseases, traits or outcomes.
3. OMICs studies relating to genetic and/or epigenetic regulations.
4. Genetic biomarker-based analysis and prognosis.
5. Molecular targets and therapeutic approaches.
6. Genetic engineering 
7. Methods development or improvement of state-of-the-art processes.

Issue: December 2025
Submission Deadline: 31^st July, 2025