EPMA Journal - Featured article: Muti-omics integration analysis revealed molecular network alterations in human nonfunctional pituitary neuroendocrine tumors in the framework of 3P medicine

This month's featured article for EPMA Journal is entitled 'Muti-omics integration analysis revealed molecular network alterations in human nonfunctional pituitary neuroendocrine tumors in the framework of 3P medicine (this opens in a new tab)' by Siqi Wen, Chunling Li & Xianquan Zhan. 

Pituitary neuroendocrine tumors (PitNETs) are the second most common primary central nervous system tumors in adults. Among them, non-functional PitNET (NF-PitNET), a PitNET with hormone synthesis but without hormone hypersecretion symptoms, is accounted for 15 ~ 54%. A series of molecules are involved in NF-PitNET pathogenesis that alter in multiple levels of genome, transcriptome, proteome, and metabolome. These molecules mutually interact to form dynamically associated molecular-network systems. 

In this review article, Wen and colleagues explore the current knowledge of single omics and integrative omics of NF-PitNETs and highlight key signaling pathways and signaling pathway network alterations identified from multi-omics data. Researcher emphasized the altered signaling pathways and their key molecules related to NF-PitNET invasiveness and aggressiveness that are challenging clinical problems.