Featured article: Targeting the endocannabinoid system

Cannabis-inspired medical products are garnering increasing attention from the scientific community, general public, and health policy makers. A plethora of scientific literature demonstrates intricate engagement of the endocannabinoid system with human immunology, psychology, developmental processes, neuronal plasticity, signal transduction, and metabolic regulation. Despite the therapeutic potential, the adverse psychoactive effects and historical stigma, cannabinoids have limited widespread clinical application. 

In this review, Reddy et al outline of the endocannabinoid system and provide an in-depth discussion of the therapeutic interventions by endocannabinoids in various neurological disorders.

© Reddy et al, 2019

The endocannabinoid system in normal cellular homeostasis and its dysregulation in different neuropathologies. Schematic diagram shows ECS and its different components in normal cellular physiology. The dysregulated ECS as result of injury or pathologies to brain, becomes inefficient to maintain cellular homeostasis, and exaggerates the progression of different neurological disorders.