Diabetologia - Special Issue: Developmental Origins
Type 2 diabetes, once considered a disease of old age, sadly now occurs not uncommonly in children and young adults. Diabetes thus affects everyone, from cradle to grave, and thus we have chosen ‘A life course perspective on diabetes: developmental origins and beyond’ as the theme of our 2019 special issue. The issue covers evolution and the diabesity epidemic, racial and sex differences in the burden of type 2 diabetes, under- and overnutrition and obesity/diabetes risk, maternal and paternal in utero programming, environmental agents as diabetes risk factors, the impact of early-life factors on type 1 diabetes, and cellular senescence and ageing effects in diabetes. We conclude with a piece tackling the question: what should governments do?
A life course perspective on diabetes: developmental origins and beyond (this opens in a new tab). Sally M. Marshall. DOI: 10.1007/s00125-019-4954-6.
The diabesity epidemic in the light of evolution: insights from the capacity–load model (this opens in a new tab). Jonathan C. K. Wells. DOI: 10.1007/s00125-019-4944-8.
Racial/ethnic differences in the burden of type 2 diabetes over the life course: a focus on the USA and India (this opens in a new tab). Sherita H. Golden, Chittaranjan Yajnik, Sanat Phatak, et al. DOI: 10.1007/s00125-019-4968-0.
Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course (this opens in a new tab). Amy G. Huebschmann, Rachel R. Huxley, Wendy M. Kohrt, et al. DOI: 10.1007/s00125-019-4939-5.
Developmental undernutrition, offspring obesity and type 2 diabetes (this opens in a new tab). Aryeh D. Stein, Okezi E. Obrutu, Rishikesh V. Behere, et al. DOI: 10.1007/s00125-019-4930-1.
Developmental overnutrition and obesity and type 2 diabetes in offspring (this opens in a new tab). Wei Perng, Emily Oken & Dana Dabelea. DOI: 10.1007/s00125-019-4914-1.
Intrauterine programming of obesity and type 2 diabetes (this opens in a new tab). Denise S. Fernandez-Twinn, Line Hjort, Boris Novakovic, et al. DOI: 10.1007/s00125-019-4951-9.
Paternal impact on the life course development of obesity and type 2 diabetes in the offspring (this opens in a new tab). Gemma C. Sharp & Debbie A. Lawlor. DOI: 10.1007/s00125-019-4919-9.
Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors (this opens in a new tab). Robert M. Sargis & Rebecca A. Simmons. DOI: 10.1007/s00125-019-4940-z.
Early-life factors contributing to type 1 diabetes (this opens in a new tab). Maria E. Craig, Ki Wook Kim, Sonia R. Isaacs, et al. DOI: 10.1007/s00125-019-4942-x.
Cellular senescence: at the nexus between ageing and diabetes (this opens in a new tab). Allyson K. Palmer, Birgit Gustafson, James L. Kirkland, et al. DOI: 10.1007/s00125-019-4934-x.
What should governments be doing to prevent diabetes throughout the life course? (this opens in a new tab) Patrick Timpel, Lorenz Harst, Doreen Reifegerste, et al. DOI: 10.1007/s00125-019-4941-y.