Call for Papers

White matter lesions in age-related cognitive decline: etiology, risk factors, prevention and repair

Associate Editors Drs. Anna Csiszar and Farzaneh Sorond along with the Editor-in-Chief Dr. Zoltan Ungvari, and the editorial team of GeroScience (Journal of the American Aging Association) in collaboration with the newly established “Albert Research Institute for White Matter and Cognition” ( invite submission of original research articles, opinion papers and review articles related to research focused on understanding the role of white matter disease in age-related cognitive decline. White matter hyperintensities (WMH) on brain MRI are perpetual findings in an aging brain, and strongly associated with cardiovascular risk factors, cognitive decline and dementia. Yet, our mechanistic understanding of the white matter lesion etiology in dementia is entirely unexploited and poorly understood.  

This call-for-papers is aimed at providing a platform for the dissemination of critical novel ideas related to brain white matter injury and repair mechanisms, which are critical to the functional interplay between neurons, vessels, and glial cells (neurovascular unit) and the plasticity of the myelinated axons, and ultimately brain health across life span. We welcome manuscripts focusing on preclinical models of adaptive myelination, neurodegeneration, neurovascular inflammation and cerebrovascular regulation, targeting the role of endothelium, pericytes, microglia, oligodendrocytes, the neurovascular unit and the oligovascular niche.  Similarly, human clinical, biomarker and imaging studies exploring these mechanisms in age-related cognitive declines are also invited. Manuscripts exploring the causal role of molecular mechanisms of white matter plasticity and repair as they are related to lifestyle (e.g., diet, exercise, smoking), medical (e.g. blood pressure, cancer treatments), or environmental exposures are of particular interest. Authors are also encouraged to submit manuscripts focusing on translational aspects of brain white matter and cognition research. 

All manuscripts accepted from this Call for Papers will be included in a unique online article collection to further highlight the importance of this topic. All manuscripts should be submitted online here:

Please indicate during the submission process by checking the relevant box that the manuscript is submitted in response to this Call for Papers. Manuscripts will undergo normal peer review as they are received. Manuscripts will be published online as they are accepted. Articles published from this Call for Papers will be highlighted with a special “Call for Papers” banner on the article PDF, as well as included in the " White matter lesions in age-related cognitive decline” online article collection at time of publication. Submission of cover image ideas is encouraged. The submission of manuscripts in response to this Call for Papers is continuous. If you have any question please contact Dr. Farzaneh Sorond ( or Dr. Anna Csiszar ( via email.