Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis
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The Official Journal of the International Purine Club
This journal presents a forum for the publication of papers in the rapidly growing area of Purinergic Signalling (through purines and pyrimidines), with its exceptionally wide spectrum of signalling functions in health and disease. Coverage includes original articles, reviews, hot topics and controversies, and meeting reports.
There is both short-term purinergic signalling in transmission and secretion and long-term (trophic) signalling in controlling cell proliferation, differentiation, motility and death in development and regeneration. At the molecular level, rapid progress has been made in understanding the mechanisms of nucleotide and nucleoside release, their extracellular metabolism, the intracellular signalling cascades elicited by receptor activation and the cross-talk with other essential signalling pathways. In addition to basic research into the roles of purines and pyrimidines in physiological conditions, a recent emphasis is on translational research and the therapeutic opportunities concerning purinergic signalling.
Volume 19
Small molecules and biologics for future purinergic therapeutics
Purinergic Signalling is inviting submissions to the following special thematic issues:
Small molecules and biologics for future purinergic therapeutics
A Tribute to Maria Teresa Miras Portugal
Obituary: Professor Dr. Geoffrey Burnstock (1929–2020)
Professor Geoffrey Burnstock, a great luminary in science and the founder of our field of purinergic signalling, sadly died peacefully in Melbourne, Australia, on the 2nd of June, 2020, at the age of 91. Purinergic Signalling, the journal that he founded and led for so many years, are creating a page on its website that will be dedicated to your tributes to and memories of Geoff. Please share these by emailing them to Dr. Charles Kennedy, deputy Editor-in-Chief, Purinergic Signalling, at c.kennedy@strath.ac.uk by November 1st 2020.
Purinergic Signalling has introduced a new type of article, Journal Club, that comprises a short review of recent, important papers in our field that have been published in other major scientific journals, such as Nature and Science. Please see the PDF file for details.
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