This journal presents a forum for the publication of papers in the rapidly growing area of Purinergic Signalling (through purines and pyrimidines), with its exceptionally wide spectrum of signalling functions in health and disease. Coverage includes original articles, reviews, hot topics and controversies, and meeting reports.

There is both short-term purinergic signalling in transmission and secretion and long-term (trophic) signalling in controlling cell proliferation, differentiation, motility and death in development and regeneration. At the molecular level, rapid progress has been made in understanding the mechanisms of nucleotide and nucleoside release, their extracellular metabolism, the intracellular signalling cascades elicited by receptor activation and the cross-talk with other essential signalling pathways. In addition to basic research into the roles of purines and pyrimidines in physiological conditions, a recent emphasis is on translational research and the therapeutic opportunities concerning purinergic signalling.

  • Responds to rapidly growing interest in purinergic signalling
  • Presents original articles, reviews, hot topics and controversies, and meeting reports

Journal information

  • Charles Kennedy
Publishing model
Hybrid (Transformative Journal). Learn about publishing Open Access with us

Journal metrics

3.765 (2020)
Impact factor
4.131 (2020)
Five year impact factor
55 days
Submission to first decision
95 days
Submission to acceptance
94,773 (2020)

Latest articles

Journal updates

  • Announcement: COVID-19 impact on peer review

    As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times. Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

  • Call for Papers

    Purinergic Signalling is inviting submissions to the following special thematic issues:

    The contribution of pannexin-1, connexins and CALHM ATP-release channels to purinergic signalling 

    Purinergic signalling- a perspective from China

    Purinergic signalling and Calcification

    Small molecules and biologics for future purinergic therapeutics

  • Tributes and memories to Professor Geoff Burnstock

    Obituary: Professor Dr. Geoffrey Burnstock (1929–2020)

    Professor Geoffrey Burnstock, a great luminary in science and the founder of our field of purinergic signalling, sadly died peacefully in Melbourne, Australia, on the 2nd of June, 2020, at the age of 91. Purinergic Signalling, the journal that he founded and led for so many years, are creating a page on its website that will be dedicated to your tributes to and memories of Geoff. Please share these by emailing them to Dr. Charles Kennedy, deputy Editor-in-Chief, Purinergic Signalling, at by November 1st 2020.

  • Journal Club

    Purinergic Signalling has introduced a new type of article, Journal Club, that comprises a short review of recent, important papers in our field that have been published in other major scientific journals, such as Nature and Science. Please see the PDF file for details.

View all updates


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