Journal of Pharmacokinetics and Pharmacodynamics Special Issue on Chronopharmacometrics

Chronopharmacology is part of pharmacology that is concerned with effects of biological rhythms while pharmacometrics relates to mathematical models of pharmacokinetics and pharmacodynamics of drugs. Chronopharmacometrics encompasses pharmacometric methods relevant to quantifying chronopharmacology and chronotherapeutics. We are planning a special issue of Journal of Pharmacokinetics and Pharmacodynamics on Chronopharmacometrics in December 2020 to present state-of-the-art modeling approaches that address the presence of biorhythms in biomarkers used in drug development and therapeutics. Potential topics will include but not be limited to:

  • Examples of drugs and biomarkers exhibiting biorhythms: genes, hormones, cells, physiological processes
  • Cosinor analysis and other statistical approaches to detecting and quantifying rhythms in physiological baselines
  • PKPD, PBPK, QSP models of drugs and drug effects with circadian rhythms
  • Mixed effects models of biorhythmic data
  • Time to event analysis of sleep/awake patterns
  • Optimization of dosing regimens for drugs with circadian PKPD
  • Machine learning methods for identification and quantification of biorhythms
  • Real-time data collection of digital data and biorhythms
  • Models of biorhythms in cell cycle
  • Examples of software designed for analysis of biorhythmic data 


We invite contributions of manuscripts focusing on one of these topics. The key objective should be a brief introduction of the modeling technique and demonstration of its potential for chronopharmacology or chronotherapeutics.  The deadline for submission is September 30, 2020. Please contact Wojciech Krzyzanski at wk@buffalo.edu for further details and inquiries.