Broadly speaking, the Journal of Pharmacokinetics and Pharmacodynamics covers the area of pharmacometrics. The journal is devoted to illustrating the importance of pharmacokinetics, pharmacodynamics, and pharmacometrics in drug development, clinical care, and the understanding of drug action. The journal publishes on a variety of topics related to pharmacometrics, including, but not limited to, clinical, experimental, and theoretical papers examining the kinetics of drug disposition and effects of drug action in humans, animals, in vitro, or in silico; modeling and simulation methodology, including optimal design; precision medicine; systems pharmacology; and mathematical pharmacology (including computational biology, bioengineering, and biophysics related to pharmacology, pharmacokinetics, orpharmacodynamics). Clinical papers that include population pharmacokinetic-pharmacodynamic relationships are welcome. The journal actively invites and promotes up-and-coming areas of pharmacometric research, such as real-world evidence, quality of life analyses, and artificial intelligence. The Journal of Pharmacokinetics and Pharmacodynamics is an official journal of the International Society of Pharmacometrics.

Journal of Pharmacokinetics and Pharmacodynamics publishes six issues a year.

  • Illustrates the importance of pharmacokinetics, pharmacodynamics, and pharmacometrics
  • Presents both theoretical and experimental papers on a range of related topics
  • Includes a special section on pharmacometrics
  • Applies research findings to real-world observations

Journal information

Editor-in-Chief
  • Peter Bonate
Publishing model
Hybrid (Transformative Journal). Learn about publishing Open Access with us

Journal metrics

2.745 (2020)
Impact factor
2.751 (2020)
Five year impact factor
29 days
Submission to first decision
143,349 (2020)
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Journal updates

  • In Memoriam: Hartmut Derendorf

    The journal extends its condolences to the family of Editorial Advisory Board Member Hartmut Derendorf, who unexpectedly passed away on November 23, 2020.  He was a leader in the field and he contributed to the journal as a reviewer and author.  A commentary on his life and legacy was published in March 2021. His obituary can be found here.

  • Journal of Pharmacokinetics and Pharmacodynamics Special Issue on Chronopharmacometrics

    Chronopharmacology is part of pharmacology that is concerned with effects of biological rhythms while pharmacometrics relates to mathematical models of pharmacokinetics and pharmacodynamics of drugs. Chronopharmacometrics encompasses pharmacometric methods relevant to quantifying chronopharmacology and chronotherapeutics. 

    A special issue of Journal of Pharmacokinetics and Pharmacodynamics on Chronopharmacometrics was published in July 2021 presenting state-of-the-art modeling approaches that address the presence of biorhythms in biomarkers used in drug development and therapeutics. Potential topics included but were not limited to:

    • Examples of drugs and biomarkers exhibiting biorhythms: genes, hormones, cells, physiological processes
    • Cosinor analysis and other statistical approaches to detecting and quantifying rhythms in physiological baselines
    • PKPD, PBPK, QSP models of drugs and drug effects with circadian rhythms
    • Mixed effects models of biorhythmic data
    • Time to event analysis of sleep/awake patterns
    • Optimization of dosing regimens for drugs with circadian PKPD
    • Machine learning methods for identification and quantification of biorhythms
    • Real-time data collection of digital data and biorhythms
    • Models of biorhythms in cell cycle
    • Examples of software designed for analysis of biorhythmic data 
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Electronic ISSN
1573-8744
Print ISSN
1567-567X
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