BioSensing, Theranostics, and Medical Devices

1. Front Matter

   Pages i-ix

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2. Gold Nanoclusters as Emerging Theranostic Interventions for Biomedical Applications

   • Kritika Sood, Asifkhan Shanavas

   Pages 1-31

3. Advances in Materials, Methods, and Principles of Modern Biosensing Tools

   • Mitali Basak, Shirsendu Mitra, Dipankar Bandyopadhyay

   Pages 33-57

4. Evolution Towards Theranostics: Basic Principles

   • Pallavi Kiran, Amreen Khan, Suditi Neekhra, Pankaj Kumar, Barkha Singh, Shubham Pallod et al.

   Pages 59-82

5. Biosensor-Based Point-of-Care Devices: Metabolites and Pulse Oximetry

   • Inga M. Hwang, Xuwen A. Lou, Adam A. Toubian, Daniel T. Kamei

   Pages 83-104

6. Biosensor-Based Point-of-Care Devices: Detection of Infectious Diseases and Cancer

   • Inga M. Hwang, Cassandra M. Cantu, Rohan Chawla, Daniel T. Kamei

   Pages 105-132

7. Non-invasive Cellular Characterization Using Bioimpedance Sensing

   • Debanjan Das, Soumen Das

   Pages 133-164

8. Research Aspects and Strategies for the Development of Biosensors for Renal Disease Diagnosis

   • Akshay Srivastava, Gopal Agarwal

   Pages 165-183

9. From Natural to Artificial Biorecognition Elements: From Antibodies to Molecularly Imprinted Polymers

   • Jaroslava Bezdekova, Tomas Rypar, Marcela Vlcnovska, Marketa Vaculovicova, Mirek Macka

   Pages 185-206

10. Design and Development of a Bed-Side Cardiac Health Monitoring Device

    • Sudipta Ghosh, Jayanta Mukhopadhyay, Manjunatha Mahadevappa

    Pages 207-232

11. Tailoring Multi-Functional 1D or 2D Nanomaterials: An Approach towards Engineering Futuristic Ultrasensitive Platforms for Rapid Detection of Microbial Strains

    • Preetam Guha Ray, Baisakhee Saha, Pravin Vaidya, Hema Bora, Krishna Dixit, Asmita Biswas et al.

    Pages 233-264

12. Clinical Validation of the Medical Devices: A General Prospective

    • Sumanta Ghosh, Dipesh Shah, Namdev More, Mounika Choppadandi, Deepak Ranglani, Govinda Kapusetti

    Pages 265-297

13. Dried Blood Patterns for Diagnosis of Non-Communicable and Infectious Diseases

    • Jijo Easo George, Debjani Paul

    Pages 299-316

14. Theranostics: Principles, Materials, and Technical Advancements

    • Sri Amruthaa Sankaranarayanan, Surya Prakash Singh, Aravind Kumar Rengan

    Pages 317-343

15. Nanotheranostics: Nanoparticles Applications, Perspectives, and Challenges

    • Atul Kumar Ojha, Ragavi Rajasekaran, Anurag Kumar Pandey, Abir Dutta, Venkata Sundeep Seesala, Subrata K. Das et al.

    Pages 345-376

This book provides up-to-date information on the prototypes used to develop medical devices and explains the principles of biosensing and theranostics. It also discusses the development of biosensor and application-orientated design of medical devices. In addition to summarizing the clinical validation of the developed techniques and devices and the regulatory steps involved in their commercialization, the book highlights the latest research and translational technologies toward the development of point-of-care devices in the health care. Lastly, it explores the current opportunities, challenges and provides troubleshooting on the use of biosensors in precision medicine. The book is helpful for researchers and medical professionals working in the field of clinical theranostics, and medical-device development wanting to gain a better understanding into the principles and processes involved in the development of biosensors.

• Medical Diagnostics
• Medical biosensors
• Point-of-care theranostics
• Clinical validation
• Biosensors commercialization

• Department of Medical Devices, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India

  Vivek Borse

• Department of Bioscience and Biochemical Engineering, Indian Institute of Technology, Varanasi, Uttar pradesh, India

  Pranjal Chandra

• Department of Bioscience Bioengineering, Indian Institute of Technology Bombay, Mumbai, India

  Rohit Srivastava

Vivek Borse is working as a DST INSPIRE Faculty at the Department of Medical Devices, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India. Earlier he was associated with the Centre for Nanotechnology, Indian Institute of Technology (IIT) Guwahati, Assam, India. He is a Graduate in Pharmacy with Gold Medal and University First Rank from North Maharashtra University, Jalgaon, Maharashtra. He has completed M. Tech. (Pharm.) from the National Institute of Pharmaceutical Education and Research (NIPER), Mohali. Further, he has completed PhD from the Department of Biosciences and Bioengineering, IIT Bombay, Mumbai. His thesis titled “Nanodiagnostics for Orthopedic Implant-associated Infection” was chosen for the “Award for Excellence in Thesis Work” for the year 2016–2018 for outstanding research contributions in PhD. The award was presented to Vivek Borse by the Hon. Prime Minister of India, Mr. Narendra Modi in the 56th Convocation of IIT Bombay. 

Vivek Borse has published his research work in more than 20 international journals, 5 book chapters, and a book. He has expertise in the field of nanobiotechnology, nanodiagnostics, lateral flow immunoassay (LFIA), point-of-care devices, nanomaterials, polymers, biomaterials, novel drug delivery systems, and biomedical engineering. His research area includes an interdisciplinary field of nanotechnology, biotechnology, and pharmacy providing pertinent solutions to healthcare.

Prof. Pranjal Chandra is an Assistant Professor at the School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, India. He earned his Ph.D. from Pusan National University, South Korea and did post-doctoral training at Technion-Israel Institute of Technology, Israel. His research focus is highly interdisciplinary, spanning a wide range in biotechnology, nanobiosensors, material engineering, and nanomedicine. He has designed several commercially viable biosensing prototypes that can be operated for onsite analysis for biomedical diagnostics. He has published 10 books on various aspects of biosensors/medical diagnostics from IET London, Springer Nature, CRC press USA. He has also published more than original research articles in the journals of high repute. Dr. Chandra is the recipient of many prestigious awards, coveted honors, and fellowships such as; DST Ramanujan fellowship (Government of India) ;  Early Carrier Research Award (ECRA) (DST, Government of India) ; BK -21 and NRF fellowship, South Korea ; Technion Post-Doctoral Fellowship, Israel ; Nano Molecular Society India Young Scientist Award ; Biotech Research Society India (BRSI) Young Scientist Award ; Young Engineers Award 2018 ; ACS / Elsevier Outstanding Reviewer Awards ; HIGHLY CITED Corresponding authors in The ROYAL SOCIETY OF CHEMISTRY (RSC), Cambridge, London ; Top 10% cited article in the General Chemistry Section RSC Jounal, Cambridge, London, Gandhian YoungTechnology Innovation Award (GYTI) 2020, Selected as Member of National Academy of Sciences (MNASc), India etc. Dr. Chandra also listed among the WORLD'S TOP 2% SCIENTIST in a report by Stanford University, USA. 

Prof. Rohit Srivastava is working as a Himanshu Patel Chair Professor and Head, Department of Biosciences and Bioengineering at the Indian Institute of Technology, Bombay. Dr. Srivastava completed his Bachelor of Engineering in Electronics Engineering from VNIT Nagpur in 1999 and Master of Science and a Ph.D. in Biomedical Engineering from Louisiana Tech University, Ruston, LA, USA. His specialization lies in POC Diagnostic devices, Biomedical Microsystems devices (MEMS), nanoengineered biosensors, photothermal therapy in cancers and nanoengineered orthopedic applications. Dr. Srivastava’s lab, in collaboration with Biosense Technologies Pvt. Ltd., has developed and commercialized “UChek” a portable urine analysis system based on the mobile platform and have also made a low-cost reader for quantitatively analyzing urine dipsticks for which he has received the DBT Biotech Process and Product Commercialization Award 2015 and the OPPI Young Investigator Award 2014. He has been awarded the prestigious Vasvik Award 2013 for Biological Sciences and Technology for Suchek, an indigenous, accurate, low-cost glucometer supported by the Indian Council of Medical Research. Dr. Srivastava is also the recipient of the prestigious Tata Innovation Fellowship Award from DBT for his translational work on diagnosing orthopedic implant-related infections. He has recently been awarded the prestigious DBT National Bioscience Award for translating technologies from the lab. He has recently been awarded the prestigious NASI Reliance Industries Platinum Jubilee Awards 2018 for Application Oriented Innovations in Physical Sciences. He has published more than 130 research articles in the journals of high repute and 100 international conference proceedings. He has been awarded INAE Abdul Kalam Technology Innovation Fellowship and elected as Fellow of National Academy of Science, India, Fellow of Royal Society of Chemistry (FRSC) and Fellow of Royal Society of Biology (FRSB), London.  

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