Skip to main content
SpringerLink
Log in

GM3 Signaling

  • Book
  • © 2020

Overview

Authors:
  1. Cheorl-Ho Kim

    1. Molecular and Cellular Glycobiology Lab Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, Korea (Republic of)

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • Reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells

  • Explores the ways in which GM3 exerts its effects via various growth factor receptors

  • Examines the role of GM3 in health and disease

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (23 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. History of Sialic Acids, Gangliosides, and GM3

    • Cheorl-Ho Kim
    Pages 1-2

  3. Synthesis of GM3

    • Cheorl-Ho Kim
    Pages 3-6

  4. Molecular Localization of GM3 in Cells

    • Cheorl-Ho Kim
    Pages 7-8

  5. Basic Function of GM3 as an Interacting Molecule

    • Cheorl-Ho Kim
    Pages 9-12

  6. GD3 Mimetics with a Neurite Forming Capacity

    • Cheorl-Ho Kim
    Pages 13-15

  7. GM3 as a Pathogenic Infection Receptor

    • Cheorl-Ho Kim
    Pages 17-20

  8. GM3 and Related Gangliosides Prevent Inflammation and Atherosclerosis

    • Cheorl-Ho Kim
    Pages 21-29

  9. GM3 Has an Anti-tumor Capacity

    • Cheorl-Ho Kim
    Pages 31-36

  10. GM3 Suppresses Tumor Angiogenesis

    • Cheorl-Ho Kim
    Pages 37-39

  11. Interaction Between EGFR and GM3

    • Cheorl-Ho Kim
    Pages 41-47

  12. Membrane Ganglioside-Specific Neuraminidase 3 (NEU3) Regulates GM3 Signaling

    • Cheorl-Ho Kim
    Pages 49-54

  13. Regulation of GM3-Mediated EGFR Signaling by NEU3 Sialidase

    • Cheorl-Ho Kim
    Pages 55-59

  14. VEGFR–GM3 Interaction in Angiogenesis

    • Cheorl-Ho Kim
    Pages 61-76

  15. GM3, Competing with GM1, Interaction with Urokinase Plasminogen Activator Receptor (uPAR) in Endothelial Caveolar-Lipid Rafts Inhibits Angiogenesis

    • Cheorl-Ho Kim
    Pages 77-78

  16. GM3 Interacts with TGFβRs in the Epithelial–Mesenchymal Transition (EMT) During Posterior Capsular Opacification (PCO) Formation

    • Cheorl-Ho Kim
    Pages 79-86

  17. Galectin-1 Promotes Tumor Growth and Escapes Immune Surveillance

    • Cheorl-Ho Kim
    Pages 87-91

  18. GM3-HGFR, FGFR, and PDGFR Cancer Cell Behavior and IGF-1R in Diabetic Wound Healing

    • Cheorl-Ho Kim
    Pages 93-98

  19. GM3, Caveolin-1 and Insulin Receptor in Insulin Resistance

    • Cheorl-Ho Kim
    Pages 99-103

  20. GM3 Suppresses Arthritis

    • Cheorl-Ho Kim
    Pages 105-107
Back to top

Keywords

About this book

This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.

Authors and Affiliations

  • Molecular and Cellular Glycobiology Lab Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, Korea (Republic of)

    Cheorl-Ho Kim

About the author

Prof. Cheorl-Ho Kim

Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation