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Minimal Cells: Design, Construction, Biotechnological Applications

Editors: Lara, Alvaro R., Gosset, Guillermo (Eds.)

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  • Provides an overview of the design, generation and characterization of minimal cell systems
  • Highlights advances in the generation and characterization of reduced-genome strains
  • Includes methodologies such as bottom-up and top-down genome minimization strategies
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eBook 118,99 €
price for Italia (gross)
  • ISBN 978-3-030-31897-0
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Italia (gross)
  • Atteso per: 15 febbraio 2020
  • ISBN 978-3-030-31896-3
  • Free shipping for individuals worldwide
About this book

This book provides a comprehensive overview of the design, generation and characterization of minimal cell systems. Written by leading experts, it presents an in-depth analysis of the current issues and challenges in the field, including recent advances in the generation and characterization of reduced-genome strains generated from model organisms with relevance in biotechnology, and basic research such as Escherichia coliCorynebacterium glutamicum and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g. Bacillus subtilis.

The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.



About the authors

Alvaro R. Lara was awarded a PhD in Biochemical Sciences from the Universidad Nacional Autónoma de México in 2007. He is currently an Associate Professor at the Universidad Autónoma Metropolitana. His research focuses on biological engineering, biochemical engineering and biomanufacturing using microbial and mammalian cells. He has published more than 40 research articles and book chapters, as well as 3 patents. Dr. Lara is member of the editorial board of the journals Bioprocess and Biosystems Engineering and Microbial Cell Factories.

Guillermo Gosset was awarded a Ph.D. degree in Biotechnology from the Universidad Nacional Autónoma de México (UNAM) in 1993. Since 1988 he has been a research scientist at the Biotechnology Institute/UNAM. His main research interests are related to metabolic pathway engineering and microbial physiology. Gosset’s work has appeared in more than 121 publications and been included in 8 patents. Several of these publications are utilized as examples in textbooks in the field of metabolic engineering. His industrial experience includes two years as a visiting scientist at Genencor International (Palo Alto, U.S.A.) and one year at Metabolic Explorer (Clermont-Ferrand, France). He is member of the editorial board of the Journal of Molecular Microbiology and Biotechnology, where he has been the Senior Editor since 2006. He has also been the Associate Editor of Microbial Cell Factories since 2014.


Table of contents (8 chapters)

Table of contents (8 chapters)
  • Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis

    Pages 1-44

    Ziegler, Martin (et al.)

  • Construction of Minimal Genomes and Synthetic Cells

    Pages 45-67

    Choe, Donghui (et al.)

  • Engineering Reduced-Genome Strains of Pseudomonas putida for Product Valorization

    Pages 69-93

    Wirth, Nicolas T. (et al.)

  • Genome-Reduced Corynebacterium glutamicum Fit for Biotechnological Applications

    Pages 95-116

    Wendisch, Volker F.

  • Reduction of the Saccharomyces cerevisiae Genome: Challenges and Perspectives

    Pages 117-139

    Caspeta, Luis (et al.)

Buy this book

eBook 118,99 €
price for Italia (gross)
  • ISBN 978-3-030-31897-0
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Italia (gross)
  • Atteso per: 15 febbraio 2020
  • ISBN 978-3-030-31896-3
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Minimal Cells: Design, Construction, Biotechnological Applications
Editors
  • Alvaro R. Lara
  • Guillermo Gosset
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-31897-0
DOI
10.1007/978-3-030-31897-0
Hardcover ISBN
978-3-030-31896-3
Edition Number
1
Number of Pages
VII, 230
Number of Illustrations
6 b/w illustrations, 29 illustrations in colour
Topics