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Developmental, Physiological, and Functional Neurobiology of the Inner Ear

  • Book
  • © 2022

Overview

Editors:
  1. Andrew K. Groves

    1. Department of Neuroscience, Baylor College of Medicine, Houston, USA

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Neuromethods (NM, volume 176)

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Table of contents (18 protocols)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Experimental Manipulation of the Inner Ear

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Pou4f3DTR Mice Enable Selective and Timed Ablation of Hair Cells in Postnatal Mice

      • Jennifer S. Stone, Edwin W. Rubel, Mark E. Warchol
      Pages 3-23

    3. Cochlear Explant Cultures: Creation and Application

      • Elizabeth Carroll Driver, Matthew W. Kelley
      Pages 25-40

    4. Immunohistochemistry and In Situ mRNA Detection Using Inner Ear Vibratome Sections

      • Mirko Scheibinger, Amanda Janesick, Giovanni H. Diaz, Stefan Heller
      Pages 41-58

    5. Genetic Manipulation of the Embryonic Chicken Inner Ear

      • Nicolas Daudet, Magdalena Å»ak, Thea Stole, Stephen Terry
      Pages 59-75

    6. Molecular Tools to Study Regeneration of the Avian Cochlea and Utricle

      • Amanda Janesick, Mirko Scheibinger, Stefan Heller
      Pages 77-97

  3. Molecular Analysis of the Inner Ear

    1. Front Matter

      Pages 99-99
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    2. An Efficient Method to Detect Messenger RNA (mRNA) in the Inner Ear by RNAscope In Situ Hybridization

      • Sumana Ghosh, Graham Casey, Kendra L. Stansak, Punam Thapa, Bradley J. Walters
      Pages 101-130

    3. A Manual Technique for Isolation and Single-Cell RNA Sequencing Analysis of Cochlear Hair Cells and Supporting Cells

      • Cody West, Paul T. Ranum, Ryotaro Omichi, Yoichiro Iwasa, Miles J. Klimara, Daniel Walls et al.
      Pages 131-149

    4. Ribosomal Pulldown Assays and Their Use to Analyze Gene Expression in Multiple Inner Ear Cell Types

      • Maggie S. Matern, Beatrice Milon, Ran Elkon, Ronna Hertzano
      Pages 151-171

  4. Hair Cell Function and Physiology

    1. Front Matter

      Pages 173-173
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    2. In Vivo Analysis of Hair Cell Sensory Organs in Zebrafish: From Morphology to Function

      • Saman Hussain, Roberto Aponte-Rivera, Rana M. Barghout, Josef G. Trapani, Katie S. Kindt
      Pages 175-220

    3. Electrophysiological Recordings of Voltage-Dependent and Mechanosensitive Currents in Sensory Hair Cells of the Auditory and Vestibular Organs of the Mouse

      • Artur A. Indzhykulian, Stuart L. Johnson, Gwenaëlle S. G. Géléoc
      Pages 221-264

    4. Biophysical Recording from Adult Hair Cells

      • Antonio Miguel Garcia de Diego, Jonathan F. Ashmore
      Pages 265-274

    5. Endocochlear Potential Measures, Local Drug Application, and Perilymph Sampling in the Mouse Inner Ear

      • Kevin K. Ohlemiller, Jared J. Hartsock, Alec N. Salt
      Pages 275-301

  5. The Central Auditory Pathway

    1. Front Matter

      Pages 303-303
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    2. In Vivo Whole-Cell Recording in the Gerbil Cochlear Nucleus

      • Hsin-Wei Lu, Philip X. Joris
      Pages 305-320

    3. Measurement of Human Cochlear and Auditory Nerve Potentials

      • Eric Verschooten, Philip X. Joris
      Pages 321-337

    4. Strategies for Identification of Medial Olivocochlear Neurons for Patch-Clamp Studies of Synaptic Function Using Electrical Stimulation and Optogenetics

      • Kirupa Suthakar, Lester Torres Cadenas, Catherine Weisz
      Pages 339-356
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Keywords

About this book

This volume explores the latest techniques in inner ear development, analysis of its sensory cells, and characterization and manipulation of the central auditory and vestibular pathways. The chapters in this book cover topics such as dissection and imaging of the cochlea; behavioral evaluation of animal models of diseases like tinnitus; hair cell function and regeneration; and recent advances in sequencing technology. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. 

Cutting-edge and comprehensive, Developmental, Physiological, and Function Neurobiology of the Inner Ear is a valuable resource for scientists and researchers interested in learning more about this developing field. 


Editors and Affiliations

  • Department of Neuroscience, Baylor College of Medicine, Houston, USA

    Andrew K. Groves

Bibliographic Information

  • Book Title: Developmental, Physiological, and Functional Neurobiology of the Inner Ear

  • Editors: Andrew K. Groves

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-0716-2022-9

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2022

  • Hardcover ISBN: 978-1-0716-2021-2Published: 04 January 2022

  • Softcover ISBN: 978-1-0716-2024-3Published: 05 January 2023

  • eBook ISBN: 978-1-0716-2022-9Published: 03 January 2022

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XIII, 398

  • Number of Illustrations: 1 b/w illustrations, 109 illustrations in colour

  • Topics: Neurosciences

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