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Vaccine Design

Methods and Protocols, Volume 1. Vaccines for Human Diseases

  • Book
  • © 2022

Overview

Editors:
  1. Sunil Thomas

    1. Lankenau Institute for Medical Research, Wynnewood, USA

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2410)

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Table of contents (38 protocols)

  1. Front Matter

    Pages i-xviii
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  2. Vaccines: Introduction

    1. Front Matter

      Pages 1-1
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    2. Challenges for Vaccinologists in the First Half of the Twenty-First Century

      • Sunil Thomas, Ann Abraham, Patrick J. Callaghan, Rino Rappuoli
      Pages 3-25

    3. Principles in Immunology for the Design and Development of Vaccines

      • Claudius U. Meyer, Fred Zepp
      Pages 27-56

    4. Revisiting the Principles of Designing a Vaccine

      • Shubhranshu Zutshi, Sunil Kumar, Prashant Chauhan, Bhaskar Saha
      Pages 57-91

    5. Status of COVID-19 Pandemic Before the Administration of Vaccine

      • Sunil Thomas
      Pages 93-108

  3. Trends in Vaccinology

    1. Front Matter

      Pages 109-109
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    2. mRNA Vaccines to Protect Against Diseases

      • Sunil Thomas, Ann Abraham
      Pages 111-129

    3. Artificial Intelligence in Vaccine and Drug Design

      • Sunil Thomas, Ann Abraham, Jeremy Baldwin, Sakshi Piplani, Nikolai Petrovsky
      Pages 131-146

  4. Vaccines for Human Viral Diseases

    1. Front Matter

      Pages 147-147
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    2. Vaccines Targeting Numerous Coronavirus Antigens, Ensuring Broader Global Population Coverage: Multi-epitope and Multi-patch Vaccines

      • Sukrit Srivastava, Spyros D. Chatziefthymiou, Michael Kolbe
      Pages 149-175

    3. Use of Micro-Computed Tomography to Visualize and Quantify COVID-19 Vaccine Efficiency in Free-Breathing Hamsters

      • Laura Seldeslachts, Christopher Cawthorne, Suzanne F. Kaptein, Robbert Boudewijns, Hendrik Jan Thibaut, Lorena Sanchez Felipe et al.
      Pages 177-192

    4. Design of Replication-Competent VSV- and Ervebo-Vectored Vaccines Against SARS-CoV-2

      • Qixing Liu, Zhe Ding, Jiaming Lan, Gary Wong
      Pages 193-208

    5. CRISPR Engineering of Bacteriophage T4 to Design Vaccines Against SARS-CoV-2 and Emerging Pathogens

      • Jingen Zhu, Neeti Ananthaswamy, Swati Jain, Himanshu Batra, Wei-Chun Tang, Venigalla B. Rao
      Pages 209-228

    6. Techniques for Developing and Assessing Immune Responses Induced by Synthetic DNA Vaccines for Emerging Infectious Diseases

      • Ziyang Xu, Michelle Ho, Devivasha Bordoloi, Sagar Kudchodkar, Makan Khoshnejad, Leila Giron et al.
      Pages 229-263

    7. Towards Determining the Epitopes of the Structural Proteins of SARS-CoV-2

      • Sunil Thomas
      Pages 265-272

    8. Development, Production, and Characterization of Hepatitis B Subviral Envelope Particles as a Third-Generation Vaccine

      • Juan Manuel Battagliotti, Diego Fontana, Marina Etcheverrigaray, Ricardo Kratje, Claudio Prieto
      Pages 273-287

    9. Generation of CpG-Recoded Zika Virus Vaccine Candidates

      • Ivan Trus, Daniel Udenze, Uladzimir Karniychuk
      Pages 289-302

  5. Vaccines for Human Bacterial Diseases

    1. Front Matter

      Pages 303-303
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    2. Salmonella Uptake into Gut-Associated Lymphoid Tissues: Implications for Targeted Mucosal Vaccine Design and Delivery

      • Angelene F. Richards, Fernando J. Torres-Velez, Nicholas J. Mantis
      Pages 305-324
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Keywords

About this book

This volume provides a practical guide providing step-by-step protocol to design and develop vaccines for human diseases. Divided into three volumes, Volume 1: Vaccines for Human Diseases guides readers through an introductory section on future challenges for vaccinologists and the immunological mechanism of vaccines. Chapters focus on design of human vaccines for viral, bacterial, fungal, and parasitic diseases as well as tumor vaccines. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.

Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 1: Vaccines for Human Diseases aims to be a useful practical guide to researchers to help further their study in this field.


Editors and Affiliations

  • Lankenau Institute for Medical Research, Wynnewood, USA

    Sunil Thomas

Bibliographic Information

  • Book Title: Vaccine Design

  • Book Subtitle: Methods and Protocols, Volume 1. Vaccines for Human Diseases

  • Editors: Sunil Thomas

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-1884-4

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2022

  • Hardcover ISBN: 978-1-0716-1883-7Published: 17 December 2021

  • Softcover ISBN: 978-1-0716-1886-8Published: 18 December 2022

  • eBook ISBN: 978-1-0716-1884-4Published: 16 December 2021

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XVIII, 711

  • Number of Illustrations: 25 b/w illustrations, 101 illustrations in colour

  • Topics: Chemistry/Food Science, general, Biotechnology, Biomaterials, Immunology, Medicine/Public Health, general, Human Physiology

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