Overview
- Provides readers the foundational overview on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders
- Highlights mitochondrial replacement therapy strategies in individuals with mitochondrial disease, and omics technologies to study mitochondrial biology in healthy and disease states
- Explores advancements in therapeutic approaches towards mitochondrial disease
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1158)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (15 chapters)
-
Front Matter
Keywords
About this book
Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondriain host-pathogen interactions.
Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.
Editors and Affiliations
About the editors
Prof. Mohan Babu is internationally recognized as an emerging leader in network biology, and a pioneer for mapping epistatic relationships and membrane-associated protein complexes in prokaryotes. His multidisciplinary research program focuses on characterizing protein and genetic interaction networks from microbes to mammals, and establishing new molecular mechanisms for mitochondrial proteins associated with neurodegenerative disorders. He is an editorial board member of the journal “BioEssays”, editor of the book “Prokaryotic Systems Biology” (Springer), Associate editor of “BMC Microbiology”, secretary treasurer for “Canadian Society of Microbiology”, and an advisory board member of the “International Mitochondrial Human Proteome Initiative”.
Bibliographic Information
Book Title: Mitochondria in Health and in Sickness
Editors: Andrea Urbani, Mohan Babu
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-13-8367-0
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-13-8366-3Published: 12 September 2019
Softcover ISBN: 978-981-13-8369-4Published: 12 September 2020
eBook ISBN: 978-981-13-8367-0Published: 26 August 2019
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VI, 277
Number of Illustrations: 3 b/w illustrations, 44 illustrations in colour
Topics: Cell Biology