Cadmium Toxicity

1. Front Matter

   Pages i-viii

   PDF

2. Overview

   1. Front Matter

      Pages 1-1

      PDF

   2. Historical Lessons on Cadmium Environmental Pollution Problems in Japan and Current Cadmium Exposure Situation

      • Keiko Aoshima, Hyogo Horiguchi

      Pages 3-19

3. Health Effects of Cadmium in Human Populations and its Relation to Cadmium Exposure Levels

   1. Front Matter

      Pages 21-21

      PDF

   2. Recent Clinical and Epidemiological Studies of Itai-Itai Disease (Cadmium-Induced Renal Tubular Osteomalacia) and Cadmium Nephropathy in the Jinzu River Basin in Toyama Prefecture, Japan

      • Keiko Aoshima

      Pages 23-37

   3. Novel Pathological Study of Cadmium Nephropathy of Itai-itai Disease

      • Johji Imura, Koichi Tsuneyama, Yoshihiko Ueda

      Pages 39-50

   4. Long-Term Follow-Up Study of Residents Exposed to Cadmium in Kakehashi River Basin, Ishikawa, Japan

      • Kazuhiro Nogawa, Yasushi Suwazono, Teruhiko Kido

      Pages 51-61

   5. Effects of Cadmium Exposure on Life Prognosis

      • Muneko Nishijo, Hideaki Nakagawa

      Pages 63-73

   6. Cadmium Exposure and Its Effects on the Health Status of Rice Farmers in Akita Prefecture

      • Hyogo Horiguchi

      Pages 75-83

   7. Dietary Cadmium Intake Among General Populations in Japan and East Asia

      • Masayuki Ikeda, Takao Watanabe, Haruo Nakatsuka, Shinichiro Shimbo, Chan-Seok Moon, Hyeran Yang et al.

      Pages 85-99

4. Rice Contamination by Cadmium and its Remediation

   1. Front Matter

      Pages 101-101

      PDF

   2. Regulations for Cadmium in Rice and Soil in Japan and Countermeasures to Reduce the Concentrations

      • Tomoyuki Makino, Masaharu Murakami, Satoru Ishikawa, Tadashi Abe

      Pages 103-114

   3. Molecular Mechanism of Cadmium Accumulation in Rice

      • Wenguang Wang, Naoki Yamaji, Jian Feng Ma

      Pages 115-124

   4. Mitigation Strategies for Cadmium and Arsenic in Rice

      • Tomohito Arao

      Pages 125-138

   5. Development of Low-Cadmium-Accumulating Rice

      • Satoru Ishikawa, Tadashi Abe, Masato Kuramata, Shimpei Hayashi

      Pages 139-150

5. New Aspects in the Mechanisms of Cadmium Toxicity

   1. Front Matter

      Pages 151-151

      PDF

   2. Novel Mechanisms of Cadmium-Induced Toxicity in Renal Cells

      • Jin-Yong Lee, Maki Tokumoto, Masahiko Satoh

      Pages 153-162

   3. Roles of Metal Transporters in Cellular Cadmium Transport in Mammals

      • Seiichiro Himeno, Hitomi Fujishiro

      Pages 163-178

   4. Disturbance in Phosphorus Metabolism by Cadmium Exposure

      • Shinsuke Kido, Ichiro Kaneko, Ken-ichi Miyamoto

      Pages 179-190

6. Correction to: Recent Clinical and Epidemiological Studies of Itai-Itai Disease (Cadmium-Induced Renal Tubular Osteomalacia) and Cadmium Nephropathy in the Jinzu River Basin in Toyama Prefecture, Japan

   • Keiko Aoshima

   Pages C1-C1

This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pathophysiology of itai-itai disease, a serious condition caused by Cd pollution.


Cadmium -New Aspects in Human Disease, Rice Contamination, and Cytotoxicity- is a valuable resource for scientists involved in heavy metal toxicology, botanical sciences, and regulatory sciences. Addressing the features of Cd pollution in the past and in the present, as well as future perspectives, this is a must-have book for students, researchers and practitioners interested in global and local metal pollution.

• Cd
• Itai-Itai Desiase
• Cadmium Exposure
• Cadmium Toxicity
• Cadmium Pollution
• Heavy Metal Toxicology
• Botanical Science
• Regulatory Science

“This well‐written book provides a brief overview of aspects of cadmium toxicity, with a special emphasis on cadmium toxicity and its associated pathology in Japan. It will be useful to readers interested in understanding cadmium toxicity, particularly those who live in and around Japan.” (Partha Kasturi,Doody's Book Reviews, June 21 2019)

• Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

  Seiichiro Himeno

• Hagino Hospital, Toyama, Japan

  Keiko Aoshima

Policies and ethics