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Myosins

A Superfamily of Molecular Motors

  • Book
  • © 2020

Overview

Editors:
  1. Lynne M. Coluccio

    1. Department of Physiology & Biophysics, Boston University School of Medicine, Boston, USA

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  • Comprehensive account of the current understanding of molecular motors
  • Compiled by a group of international experts on myosin motor structure and function
  • Crucial reference for investigators and students

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1239)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Introduction

    • Lynne M. Coluccio
    Pages 1-6

  3. Myosin Structures

    • H. Lee Sweeney, Anne Houdusse, Julien Robert-Paganin
    Pages 7-19

  4. Cargo Binding by Unconventional Myosins

    • Jianchao Li, Mingjie Zhang
    Pages 21-40

  5. The Structure of Acto-Myosin

    • Rasmus R. Schröder
    Pages 41-59

  6. Small Molecule Effectors of Myosin Function

    • Dietmar J. Manstein, Matthias Preller
    Pages 61-84

  7. Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction

    • Yasuharu Takagi, Nikolas Hundt, Adam Fineberg
    Pages 85-126

  8. High-Speed Atomic Force Microscopy to Study Myosin Motility

    • Noriyuki Kodera, Toshio Ando
    Pages 127-152

  9. How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches

    • James R. Sellers, Yasuharu Takagi
    Pages 153-181

  10. How Actin Tracks Affect Myosin Motors

    • Alicja Santos, Yauhen Shauchuk, Urszula CichoÅ„, Kevin C. Vavra, Ronald S. Rock
    Pages 183-197

  11. Myosins in the Nucleus

    • Ivan V. Maly, Wilma A. Hofmann
    Pages 199-231

  12. Myosins in Cytokinesis

    • Thomas D. Pollard
    Pages 233-244

  13. Myosins and Disease

    • Lynne M. Coluccio
    Pages 245-316

  14. Myosins and Hearing

    • Thomas B. Friedman, Inna A. Belyantseva, Gregory I. Frolenkov
    Pages 317-330

  15. The Actomyosin Systems in Apicomplexa

    • Karine Frénal, Aarti Krishnan, Dominique Soldati-Favre
    Pages 331-354

  16. Approaches to Identify and Characterise MYO6-Cargo Interactions

    • Thomas O’Loughlin, John Kendrick-Jones, Folma Buss
    Pages 355-380

  17. Class IX Myosins: Motorized RhoGAP Signaling Molecules

    • Peter J. Hanley, Veith Vollmer, Martin Bähler
    Pages 381-389

  18. Myosin X

    • Hiroshi Tokuo
    Pages 391-403

  19. Myosin XVI

    • Beáta Bugyi, András Kengyel
    Pages 405-419

  20. Myosin XVIII

    • Manuel H. Taft, Sharissa L. Latham
    Pages 421-438
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Keywords

About this book

Myosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact.
Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.

Editors and Affiliations

  • Department of Physiology & Biophysics, Boston University School of Medicine, Boston, USA

    Lynne M. Coluccio

About the editor

Lynne Coluccio, PhD, began her career at Boston University as a Principal Scientist at the Boston Biomedical Research Institute (BBRI) in 1996. After the institute was closed in 2013, she became a Research Associate in the Department of Physiology & Biophysics at the Boston University School of Medicine and has remained since then. While at the BBRI, she played a variety of roles on the committee including as a chair of the Faculty Search Committee and as a member of the Public Relations Committee. Throughout her she career she has mentored dozens of students who have gone into academia, medicine, teaching, and music.

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