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Springer Theses

Proteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individuals

Authors: de Jesus, Jemmyson

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  • Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil
  • Helps readers understand the proteome and metallome of patients with bipolar disorder
  • Provides simple and rapid sample preparation methods to simplify complex samples Presents strategies for discovering biomarkers of human disease
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eBook 83,29 €
price for India (gross)
  • ISBN 978-3-030-29473-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 129,99 €
price for India (gross)
  • ISBN 978-3-030-29472-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD. Bipolar disorder is a psychiatric condition that affects thousands of people worldwide. The absence of biomarkers for BD has resulted in misdiagnosis and ineffective treatment in some patients, causing additional health problems and high costs for health systems. As such, this book evaluates various strategies for sample preparation for proteomic and ionomic studies in order to simplify complex serum samples and allow the quantification of chemical species (proteins and metal ions), which are potential candidates for BD biomarkers. In addition, it describes the development of a new membrane-based methodology for extracting urine proteins to be used in biomarker discovery.

About the authors

J.R. de Jesus holds a Ph.D. degree in Sciences with a focus on Analytical Chemistry from the University of Campinas (Unicamp) (2018). de Jesus has experience in the field of bioanalytics, proteomics and metallomics studies, molecular biology analysis and environmental analysis, as well as in developing sample preparation methods to simplify complex samples (biological and environmental).

Table of contents (5 chapters)

Table of contents (5 chapters)
  • Introduction

    Pages 1-4

    de Jesus, Dr. Jemmyson Romário

  • Application of Proteomic Strategy for the Identification of Differential Proteins Candidates to Biomarkers of Bipolar Disorder

    Pages 5-37

    de Jesus, Dr. Jemmyson Romário

  • Application of the Ionomic Strategy to Evaluate Difference in Metal Ion Concentration Between Patients with Bipolar Disorder and Other Psychiatric Disorder

    Pages 39-58

    de Jesus, Dr. Jemmyson Romário

  • Development of a New Polymer Membrane Based Methodology for the Characterization of the Urine Proteome

    Pages 59-73

    de Jesus, Dr. Jemmyson Romário

  • Final Conclusion

    Pages 75-76

    de Jesus, Dr. Jemmyson Romário

Buy this book

eBook 83,29 €
price for India (gross)
  • ISBN 978-3-030-29473-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 129,99 €
price for India (gross)
  • ISBN 978-3-030-29472-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individuals
Authors
Series Title
Springer Theses
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-29473-1
DOI
10.1007/978-3-030-29473-1
Hardcover ISBN
978-3-030-29472-4
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXV, 88
Topics