The Fundamentals of Modern Statistical Genetics

1. Front Matter

   Pages i-xiv

   PDF

2. Introduction to Statistical Genetics and Background in Molecular Genetics

   • Nan M. Laird, Christoph Lange

   Pages 1-13

3. Principles of Inheritance: Mendel’s Laws and Genetic Models

   • Nan M. Laird, Christoph Lange

   Pages 15-30

4. Some Basic Concepts from Population Genetics

   • Nan M. Laird, Christoph Lange

   Pages 31-43

5. Aggregation, Heritability and Segregation Analysis: Modeling Genetic Inheritance Without Genetic Data

   • Nan M. Laird, Christoph Lange

   Pages 45-66

6. The General Concepts of Gene Mapping: Linkage, Association, Linkage Disequilibrium and Marker Maps

   • Nan M. Laird, Christoph Lange

   Pages 67-86

7. Basic Concepts of Linkage Analysis

   • Nan M. Laird, Christoph Lange

   Pages 87-97

8. The Basics of Genetic Association Analysis

   • Nan M. Laird, Christoph Lange

   Pages 99-124

9. Population Substructure in Association Studies

   • Nan M. Laird, Christoph Lange

   Pages 125-137

10. Association Analysis in Family Designs

    • Nan M. Laird, Christoph Lange

    Pages 139-159

11. Advanced Topics

    • Nan M. Laird, Christoph Lange

    Pages 161-174

12. Genome Wide Association Studies

    • Nan M. Laird, Christoph Lange

    Pages 175-189

13. Looking Toward the Future

    • Nan M. Laird, Christoph Lange

    Pages 191-192

14. Back Matter

    Pages 193-223

    PDF

This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.

• Gene Mapping
• Genome Wide Association Studies
• Statistical Genetics

From the reviews:

“The book covers the historical perspective, covering the standard models and methods. … The presentation of the material is carefully thought through. There are lots of figures, many in colour, a large number of examples, numerous boxes that highlight particular derivations and computations, and exercises at the ends of the chapters. All topics are clearly discussed with due detail. I would say that, for the budding statistical geneticist, this is a must-have.” (Martin Crowder, International Statistical Review, Vol. 79 (3), 2011)

“A book that focuses on statistical methods for finding links between genes and diseases … is timely. … the authors steer us gently and diligently through material that was developed originally for postgraduate students at the Harvard School of Public Health … . ideal for a statistician intending to research in this area or simply for a curious, sufficiently qualified reader. … a lovely book, and essential reading if you are a budding GWASer, or simply interested in where your next disease will come from.” (G. Wood, Australian & New Zealand Journal of Statistics, Vol. 53 (4), 2011)

“The Fundamentals of Modern Statistical Genetics, by Dr. Nan M. Laird and Dr. Christoph Lange, is a timely reference for both researchers and students. … the book is clearly written, and it is useful for colleagues who are interested in the association analysis. Although the book primarily covers the interesting topic of association analysis, it does touch other interesting topics such as joint linkage and association mapping of complex traits.” (Ruzong Fan, Journal of the American Statistical Association, March, 2013)

• Department of Biostatistics, Harvard University, Boston, USA

  Nan M. Laird, Christoph Lange

Dr. Laird is a Professor of Biostatistics in the Biostatistics Department at the Harvard School of Public Health. Dr. Laird has contributed to methodology in many different fields, including missing data, EM-algorithm, meta-analysis, statistical genetics, and has coauthored a book with Garrett Fitzmaurice and James Ware on Applied Longitudinal Analysis. She is the recipient of many awards and prizes, including Fellow of the American Statistical Association, the American Association for the Advancement of Science, the Florence Nightingale Award, and the Janet Norwood Award.
Dr. Lange is an Associate Professor in the Biostatistics Department at the Harvard School of Public Health. After his PhD in Statistics at the University of Reading (UK), he has worked extensively in the field of statistical genetics. Dr. Lange has been the director of the Institute of Genome Mathematics at the University of Bonn and has received several awards in mathematics and genetics. Dr. Lange is the developer of the PBAT package.

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