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Ion Mobility-Mass Spectrometry

Methods and Protocols

  • Book
  • © 2020

Overview

Editors:
  1. Giuseppe Paglia

    1. Department of Medicine and Surgery, University of Milano-Bicocca, Vedano al Lambro, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Giuseppe Astarita

    1. Georgetown University, Washington, DC, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2084)

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Table of contents (19 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Fundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules

    • Caleb B. Morris, James C. Poland, Jody C. May, John A. McLean
    Pages 1-31

  3. Metabolomics and Lipidomics

    1. Front Matter

      Pages 33-33
      Download chapter PDF

    2. Utilizing Drift Tube Ion Mobility Spectrometry for the Evaluation of Metabolites and Xenobiotics

      • Melanie T. Odenkirk, Erin S. Baker
      Pages 35-54

    3. Untargeted Differential Metabolomics Analysis Using Drift Tube Ion Mobility-Mass Spectrometry

      • Rick Reisdorph, Cole Michel, Kevin Quinn, Katrina Doenges, Nichole Reisdorph
      Pages 55-78

    4. Drift-Tube Ion Mobility-Mass Spectrometry for Nontargeted ′Omics

      • Tim J. Causon, Ruwan T. Kurulugama, Stephan Hann
      Pages 79-94

    5. The Use of DMS-MS for the Quantitative Analysis of Acylcarnitines

      • Nicholas B. Vera, Michelle Clasquin, Stephen L. Coy, Paul Vouros
      Pages 95-101

    6. Traveling Wave Ion Mobility-Mass Spectrometry to Enhance the Detection of Low Abundance Features in Untargeted Lipidomics

      • Zeeshan Hamid, Andrea Armirotti
      Pages 103-117

    7. Lipidomics by HILIC-Ion Mobility-Mass Spectrometry

      • Amy Li, Kelly M. Hines, Libin Xu
      Pages 119-132

    8. A Workflow for the Identification of Mycotoxin Metabolites Using Liquid Chromatography–Ion Mobility-Mass Spectrometry

      • Laura Righetti, Chiara Dall’Asta
      Pages 133-144

    9. Quantitation of Cyclosporin A in Cell Culture Media by Differential Mobility Mass Spectrometry (DMS-MS/MS)

      • Amol Kafle, James Glick, Stephen L. Coy, Paul Vouros
      Pages 145-157

  5. Ambient Ionization and Imaging Ion Mobility-Mass Spectrometry

    1. Front Matter

      Pages 221-221
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    2. Desorption Atmospheric Pressure Photoionization Coupled with Ion Mobility-Mass Spectrometry

      • Tiina J. Kauppila
      Pages 223-233

    3. Metabolomic Profiling of Adherent Mammalian Cells In Situ by LAESI-MS with Ion Mobility Separation

      • Sylwia A. Stopka, Akos Vertes
      Pages 235-244

    4. Matrix-Assisted Laser Desorption and Desorption Electrospray Ionization Mass Spectrometry Coupled to Ion Mobility

      • James I. Langridge, Emmanuelle Claude
      Pages 245-265
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Keywords

About this book

This book focuses on ion mobility-mass spectrometry (IM-MS) and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of state-of-the-art IM-MS technology for the most common analytical applications. The chapters have been organized into four parts, each dealing with a particular set of IM-MS applications: 1) metabolomics and lipidomics; 2) proteomics and glycomics; 3) imaging and ambient ionization IM-MS; and 4) bioinformatic solutions for analyzing IM-MS data and deriving CCS values. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Ion Mobility-Mass Spectrometry: Methods and Protocols serves as anideal resource for scientists delving into the technique's unprecedented analytical advantages, enabling novel qualitative and quantitative applications for the analysis of complex biological samples.

Editors and Affiliations

  • Department of Medicine and Surgery, University of Milano-Bicocca, Vedano al Lambro, Italy

    Giuseppe Paglia

  • Georgetown University, Washington, DC, USA

    Giuseppe Astarita

Bibliographic Information

  • Book Title: Ion Mobility-Mass Spectrometry

  • Book Subtitle: Methods and Protocols

  • Editors: Giuseppe Paglia, Giuseppe Astarita

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-0030-6

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2020

  • Hardcover ISBN: 978-1-0716-0029-0Published: 15 November 2019

  • Softcover ISBN: 978-1-0716-0032-0Published: 15 November 2020

  • eBook ISBN: 978-1-0716-0030-6Published: 15 November 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 312

  • Number of Illustrations: 19 b/w illustrations, 83 illustrations in colour

  • Topics: Biochemistry, general, Mass Spectrometry

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