Innovative Bioceramics in Translational Medicine I

1. Front Matter

   Pages i-xv

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2. Biomaterials and Bioceramics—Part 1: Traditional, Natural, and Nano

   • Andy H. Choi

   Pages 1-45

3. Biomaterials and Bioceramics—Part 2: Nanocomposites in Osseointegration and Hard Tissue Regeneration

   • Andy H. Choi

   Pages 47-88

4. Natural and Synthetic Intelligent Self-healing and Adaptive Materials for Medical and Engineering Applications

   • Besim Ben-Nissan, Gina Choi, Andy H. Choi, Ipek Karacan, Louise Evans

   Pages 89-124

5. Stem Cells and Proteomics in Biomaterials and Biomedical Applications

   • Ipek Karacan, Bruce Milthorpe, Besim Ben-Nissan, Jerran Santos

   Pages 125-157

6. Antimicrobial Bioceramics for Biomedical Applications

   • Pietro Riccio, Mohadeseh Zare, Diana Gomes, David Green, Artemis Stamboulis

   Pages 159-193

7. Surface Functionalization of Titanium for the Control and Treatment of Infections

   • Masaya Shimabukuro

   Pages 195-212

8. Synthesis of Hydroxyapatite: Crystal Growth Mechanism and Its Relevance in Drug Delivery Applications

   • Yuta Otsuka

   Pages 213-229

9. Intelligent Drug Delivery System for Artificial Bone Cement Based on Hydroxyapatite-Related Organic/Inorganic Composite Materials

   • Makoto Otsuka

   Pages 231-253

10. Chitosan-Hydroxyapatite Composite Scaffolds for the Controlled Release of Therapeutic Metals Ions

    • Lukas Gritsch

    Pages 255-280

11. Alumina: Implantable Bionics and Tissue Scaffolds

    • Andrew J. Ruys, David J. Cowdery, Edwin K. L. Soh

    Pages 281-318

12. Biocomposites and Bioceramics in Tissue Engineering: Beyond the Next Decade

    • Sandra Pina, Il Keun Kwon, Rui L. Reis, J. Miguel Oliveira

    Pages 319-350

13. Back Matter

    Pages 351-356

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This book is part of a two-part volume book that highlights the latest advances in innovative bioceramics applied in the highly interdisciplinary area referred to as “translational medicine”. This volume covers the basic principles and techniques used in the manufacture of bioceramics and biocomposites for various biomedical applications including drug delivery, implantable bionics and the development of the cardiac pacemaker, and bone tissue engineering. Furthermore, self-healing materials have been attracting increasing interest in both engineering and medical applications during the past two decades. Self-healing hydrogels are particularly interesting because of their ability to repair structural damages and recover their original functions, specifically in tissue engineering.

• Translational Medicine
• Bioceramics
• Tissue Regeneration
• Drug Delivery
• Bone Tissue
• Bone Scaffolds
• Calcium Phosphate Scaffolds
• Bioceramic-Biogenic Composites
• Bone Cement
• Drug Delivery System

• Faculty of Science, University of Technology Sydney, Ultimo, Australia

  Andy H. Choi, Besim Ben-Nissan

Dr. Andy H. Choi is an early career researcher who received his Ph.D. from the University of Technology Sydney (UTS) in Australia in 2004 on the use of computer modeling and simulation known as finite element analysis (FEA) to examine the biomechanical behavior of implants installed into a human mandible. After completing his Ph.D., he expanded his research focus from FEA to sol–gel synthesis of multifunctional calcium phosphate nano-coatings and nanocomposite coatings for dental and biomedical applications. He is currently serving as an associate editor for the Journal of the Australian Ceramic Society and as an editor for a number of dentistry-related journals. In addition, he is also serving as an editorial board member for several dentistry, nanotechnology, and orthopedics journals. To date, Dr. Choi has published over 50 publications including 3 books (Thin Films and Nanocoatings of Hydroxyapatite on Titanium Implants: Production Methods and Adhesion Testing [ISBN 978-3-330-06425-6]; Anatomy, Modeling and Biomaterial Fabrication for Dental and Maxillofacial Applications [eISBN: 978-1-68108-691-0, 2018; ISBN: 978-1-68108-692-7]; Marine-Derived Biomaterials for Tissue Engineering Applications [ISBN: ISBN: 978-981-13-8855-2) and 30 chapters on calcium phosphate, nano-biomaterial coatings, sol-gel technology, marine structures, drug delivery, tissue engineering, and finite element analysis in nanomedicine and dentistry.




Professor Basim Ben-Nissan has higher degrees in Metallurgical and Materials Engineering (ITU), Ceramic Engineering (University of New South Wales) and a Ph.D. in Mechanical and Industrial Engineering–Biomedical Engineering (University of New South Wales). Over the last four decades together with a large numbers of Ph.D. students and postdoctoral fellows and surgeons, he has worked on production and analysis of various biomedical materials, implants, slow drug delivery devices, calcium phosphate ceramics,advanced ceramics (alumina, zirconia, silicon nitrides), sol–gel developed nanocoatings for enhanced bioactivity, antimicrobial coatings, corrosion and abrasion-resistant coatings, optical and electronic ceramics, and thermally insulating new generation composites.


In the biomedical field, he has involved with the development of materials for antimicrobial drug delivery, stem cell research, cell culture studies and cytotoxicity, natural and marine derived materials, implant technology (bioactive materials including conversion of Australian corals to hydroxyapatite and other bone grafts), biomimetics (learning from nature and its application to regenerative medicine), bio-composites, investigative research on biomechanics and finite element analysis (mandible, knee, hip joints, hip resurfacing, femoral head stresses), and reliability and implant design (modular ceramic knee prosthesis, femoral head stresses). He was part of a research team which initiated the world’s first reliable ceramic knee and hydroxyapatite sol–gel-derived nanocoatings and recently bioprinting and proto-cell research. 


Since 1990, he has published over 270 papers in journals, 60 chapters, and edited and co-edited 7 books. He is the chief editor of the Journal of the Australian Ceramic Society and the editorial board member of three international biomaterials journals. He was awarded “The Australasian Ceramic Society Award” for his contribution to the “Ceramic Education and Research in Australia.” He also received “Future Materials Award” for his contribution in the “Advanced Nanocoated Materials.” 


He has collaborated with several international groups from Japan, USA, Thailand, Finland, Israel, France, UK, Germany, and Turkey and held grants from the Australian Academy of Science, European Commission-HORIZON2020 and the Japan Society for Promotion of Science grants for collaborative work in the biomedical field. After serving as an academic for over 33 years, he has retired from teaching, however, still is active and contributes to science by research in the translational medicine, biomedical field, and supervising of higher degree students.

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