Springer Theses

Development of Selective DNA-Interacting Ligands

Understanding the Function of Non-canonical DNA Structures

Authors: Asamitsu, Sefan

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  • Nominated as an outstanding Ph.D. thesis by Kyoto University  
  • Includes systematic and exhaustive reviews of non-canonical DNA structures  
  • Offers extensive information on the synthesis of molecules, in an easy-to-follow format
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eBook 117,69 €
price for Spain (gross)
  • ISBN 978-981-15-7716-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
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Hardcover 145,59 €
price for Spain (gross)
About this book

This book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases.  
Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity.   
This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to the development of highly selective drugs or diagnostic chemical tools for human diseases. Readers who want to know how synthetic ligands can be designed to selectively target a certain DNA molecule will find this book highly informative.   

About the authors

Sefan Asamitsu obtained his B.Sc. degree from Kyoto University in 2014. He also obtained his M.Sc. degree in 2016 and his Ph.D. degree in 2019 from the Department of Chemistry at Kyoto University in the group led by Prof. Hiroshi Sugiyama. His Ph.D. thesis focuses on the development of highly selective and bioactive DNA-interactive ligands with the aim of creating potential molecular probes and therapeutic agents.

Table of contents (4 chapters)

Table of contents (4 chapters)
  • Introduction

    Pages 1-44

    Asamitsu, Dr. Sefan

  • Sequence-Specific DNA Alkylation and Transcriptional Inhibition by Long-Chain Hairpin Pyrrole–Imidazole Polyamide–Chlorambucil Conjugates Targeting CAG/CTG Trinucleotide Repeats

    Pages 45-67

    Asamitsu, Dr. Sefan

  • Ligand-Mediated G-Quadruplex Induction in a Double-Stranded DNA Context by Cyclic Imidazole/Lysine Polyamide

    Pages 69-83

    Asamitsu, Dr. Sefan

  • Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-Binding Components to a G-Quadruplex and Its Proximal Duplex

    Pages 85-109

    Asamitsu, Dr. Sefan

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-981-15-7716-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover 145,59 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Development of Selective DNA-Interacting Ligands
Book Subtitle
Understanding the Function of Non-canonical DNA Structures
Authors
Series Title
Springer Theses
Copyright
2020
Publisher
Springer Singapore
Copyright Holder
The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-15-7716-1
DOI
10.1007/978-981-15-7716-1
Hardcover ISBN
978-981-15-7715-4
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XIII, 111
Number of Illustrations
12 b/w illustrations, 56 illustrations in colour
Topics