Overview
- Nominated as an outstanding Ph.D. thesis by Kyoto University
- Includes systematic and exhaustive reviews of non-canonical DNA structures
- Offers extensive information on the synthesis of molecules, in an easy-to-follow format
Part of the book series: Springer Theses (Springer Theses)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (4 chapters)
Keywords
About this book
Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity.
This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to the development of highly selective drugs or diagnostic chemical tools for human diseases. Readers who want to know how synthetic ligands can be designed to selectively target a certain DNA molecule will find this book highly informative.
Authors and Affiliations
About the author
Bibliographic Information
Book Title: Development of Selective DNA-Interacting Ligands
Book Subtitle: Understanding the Function of Non-canonical DNA Structures
Authors: Sefan Asamitsu
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-981-15-7716-1
Publisher: Springer Singapore
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2020
Hardcover ISBN: 978-981-15-7715-4Published: 17 September 2020
Softcover ISBN: 978-981-15-7718-5Published: 18 September 2021
eBook ISBN: 978-981-15-7716-1Published: 16 September 2020
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XIII, 111
Number of Illustrations: 12 b/w illustrations, 56 illustrations in colour