Applications of Microfluidic Systems in Biology and Medicine

1. Front Matter

   Pages i-viii

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2. Acoustofluidic Blood Component Sample Preparation and Processing in Medical Applications

   • Maria Antfolk, Thomas Laurell

   Pages 1-25

3. Microfluidic Technologies and Platforms for Protein Crystallography

   • Masatoshi Maeki, Manabu Tokeshi

   Pages 27-51

4. Application of SERS-Based Microfluidics for In Vitro Diagnostics

   • Jinhyeok Jeon, Namhyun Choi, Joung-Il Moon, Hao Chen, Jaebum Choo

   Pages 53-70

5. Miniaturized Electrochemical Sensors to Facilitate Liquid Biopsy for Detection of Circulating Tumor Markers

   • Yi-Ge Zhou, Leyla Kermansha, Libing Zhang, Reza M. Mohamadi

   Pages 71-98

6. Spiral Inertial Microfluidics for Cell Separation and Biomedical Applications

   • Ning Liu, Chayakorn Petchakup, Hui Min Tay, King Ho Holden Li, Han Wei Hou

   Pages 99-150

7. Worms on a Chip

   • Han-Sheng Chuang, Wen-Hui Wang, Chang-Shi Chen

   Pages 151-196

8. Microfluidic Devices for Gamete Processing and Analysis, Fertilization and Embryo Culture and Characterization

   • Séverine Le Gac, Verena Nordhoff, Bastien Venzac

   Pages 197-225

9. Microfluidic Organs-on-Chips to Reconstitute Cellular Microenvironments

   • Yu-suke Torisawa

   Pages 227-246

10. In Vitro Tissue Construction for Organ-on-a-Chip Applications

    • Yuya Morimoto, Nobuhito Mori, Shoji Takeuchi

    Pages 247-274

11. Nanobiodevices for Cancer Diagnostics and Stem Cell Therapeutics

    • Daisuke Onoshima, Hiroshi Yukawa, Yoshinobu Baba

    Pages 275-300

12. Nanopore Device for Single-Molecule Sensing Method and Its Application

    • Masateru Taniguchi, Takahito Ohshiro

    Pages 301-324

13. Paper Microfluidics for POC Testing in Low-Resource Settings

    • Elain Fu

    Pages 325-352

14. Paper-Based Microfluidics for Point-of-Care Medical Diagnostics

    • Kentaro Yamada, Daniel Citterio

    Pages 353-382

This book focuses on state-of-the-art microfluidic research in medical and biological applications. The top-level researchers in this research field explain carefully and clearly what can be done by using microfluidic devices. Beginners in the field —undergraduates, engineers, biologists, medical researchers—will easily learn to understand microfluidic-based medical and biological applications. Because a wide range of topics is summarized here, it also helps experts to learn more about fields outside their own specialties. The book covers many interesting subjects, including cell separation, protein crystallization, single-cell analysis, cell diagnosis, point-of-care testing, immunoassay, embyos/worms on a chip and organ-on-a-chip. Readers will be convinced that microfluidic devices have great potential for medical and biological applications.

• Microfluidic device
• Lab on a chip
• Medical diagnosis
• Single cell
• Organ on a chip
• microarrays

• Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Sapporo, Japan

  Manabu Tokeshi

Manabu Tokeshi is a professor in the Division of Applied Chemistry at Hokkaido University. He is also a visiting professor at the ImPACT Research Center for Advanced Nanobiodevices, the Innovative Research Center for Preventive Medical Engineering, and the Institute of Innovation for Future Society at Nagoya University. He received his Ph.D. degree from Kyushu University in 1997. Following his work as a research fellow of the Japan Society of Promotion of Science at The University of Tokyo, he worked at the Kanagawa Academy of Science and Technology as a research staff member (1998–1999), a group subleader (1999–2003), and a group leader (2003–2004). He also served at the Institute of Microchemistry Technology Co. Ltd. as president (2004–2005) and at Nagoya University as an associate professor (2005–2011). In 2011, Dr. Tokeshi was at the Karolinska Institutet in Sweden as a visiting researcher, after which joined Hokkaido University as a professor. His honors include the Outstanding Researcher Award on Chemistry and Micro-Nano Systems from the Society for Chemistry and Micro-Nano Systems (2007), the Pioneers in Miniaturisation Prize from the Lab on a Chip (The Royal Society of Chemistry)/Corning Inc. (2007), and the Masao Horiba Award from HORIBA, Ltd. (2011). His research interests are in the development of micro- and nano-systems for chemical, biochemical, and clinical applications. 

Contributors:

Thomas Laurell, Lund University

Manabu Tokeshi, Hokkaido University

Jaebum Choo, Chung-Ang University

Reza M. Mohamadi, University of Toronto

Hou Han Wei, Nanyang Technological University

Han-Sheng Chung, National Cheng Kung University

Severine Le Gac, University of Twente

Yu-suke Torisawa, Kyoto University

Shoji Takeuchi, The University of Tokyo

Yoshinobu Baba, Nagoya University

Masateru Taniguchi, Osaka University

Elain Fu, Oregon State University

Citterio Daniel, Keio University

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